Dear Colleagues,

Metabolic and energetic disturbances have recently been considered not only as a consequence, but also as one of the causes of neurodegeneration. A well-known attribute of neurodegenerative diseases, such as in Alzheimer's disease, Parkinson's disease and others, is the progressive loss of neurons. Despite the fact that the causes of these diseases can be polyetiological, they have a wide range of similar molecular and cellular pathophysiological processes, namely protein aggregation, glutamate toxicity, calcium, proteolytic and oxidative stress, neuroinflammation, mitochondrial dysfunction, hormonal changes and others, associated with aging.

Neurodegenerative diseases are age dependent, so their development is closely related to common aging mechanisms and metabolic lesions. Cell cultures, animal models, and human studies show close connection between neurodegeneration and metabolic alterations, namely, obesity, glucose metabolism disturbances, and impairments in hormone secretion, including melatonin, leptin, ghrelin, etc. Although many have known about the pathogenesis of neurodegenerative diseases, they still do not have a therapy capable of stopping the progression and modern methods are directed at the symptoms of the disease.

This Special Issue aims to highlight the numerous metabolic changes in neurodegenerative diseases and related current therapeutic approaches.

Dr. Sandeep Singh
Prof. Dr. Soraya L. Valles
Dr. Burkhard Poeggeler
Dr. Anastasiia D. Shkodina
Guest Editors

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• Parkinson’s disease
• Alzheimer’s disease
• metabolism
• metabolites
• hormones
• inflammation
• neurodegeneration
• drug discovery
• therapy