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Targeting Inflammaging and Degeneration by Amino Acids

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 3653

Special Issue Editor


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Guest Editor
Department of Physiology, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, Faculty of Biology Georg August University Göttingen, Göttingen and Goettingen Research Campus, Göttingen, Am Türmchen 3, D-33332 Gütersloh, Germany
Interests: aging; amino acids; antioxidants; inflammaging; melatonin; product development; tryptophan
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Special Issue Information

Dear Colleagues,

The process of ageing and stress or aberrant signaling-induced senescence can induce inflammation and degeneration. Oxidative stress affects signaling pathways for metabolic protein turnover that can recruit malfunctioning aberrant proteins and compounds that trigger inflammatory processes. Although various cell types, such as skin cells, fibroblasts, muscle cells, parenchymal cells, immune cells, neurons, endocrine, endothelial and fat cells, are involved in secreting proinflammatory signals, the lack of trophic prosurvival signaling by amino acids and the resulting insufficient antioxidative protection by amino acid metabolites derived from the symbiotic organisms in the gastrointestinal tract and the endothelial cells of the cardiovascular system or the myocytes from the muscles seem to contribute most to age-dependent inflammatory processes that impair health. Recent studies have emphasized the role of metabolic mitochondrial dysregulation in degenerative inflammatory diseases.

This Special Issue focuses on these detrimental metabolic und immune responses during ageing and invites contributions to this rapidly developing field of research with special emphasis on approaches that successfully target inflammation and degeneration by providing amino acids as the decisive molecules enabling endogenous regeneration.

Dr. Burkhard Poeggeler
Guest Editor

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Keywords

  • amino acid
  • inflammation
  • degeneration
  • proinflammatory signals
  • oxidative stress
  • antioxidative protection
  • metabolites

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Published Papers (1 paper)

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Review

12 pages, 1762 KiB  
Review
Macrophages, Metabolites, and Nucleosomes: Chromatin at the Intersection between Aging and Inflammation
by Michael C. Church, Jerry L. Workman and Tamaki Suganuma
Int. J. Mol. Sci. 2021, 22(19), 10274; https://doi.org/10.3390/ijms221910274 - 24 Sep 2021
Cited by 10 | Viewed by 2985
Abstract
Inflammation is the body’s means of defense against harmful stimuli, with the ultimate aim being to restore homeostasis. Controlled acute inflammation transiently activates an immune response and can be beneficial as protection against infection or injury. However, dysregulated inflammatory responses, including chronic inflammation, [...] Read more.
Inflammation is the body’s means of defense against harmful stimuli, with the ultimate aim being to restore homeostasis. Controlled acute inflammation transiently activates an immune response and can be beneficial as protection against infection or injury. However, dysregulated inflammatory responses, including chronic inflammation, disrupt the immune system’s ability to maintain homeostatic balance, leading to increased susceptibility to infection, continuous tissue damage, and dysfunction. Aging is a risk factor for chronic inflammation; their coincidence is termed “inflammaging”. Metabolic disorders including obesity, neurodegenerative diseases, and atherosclerosis are often encountered in old age. Therefore, it is important to understand the mechanistic relationship between aging, chronic inflammation, and metabolism. It has been established that the expression of inflammatory mediators is transcriptionally and translationally regulated. In addition, the post-translational modification of the mediators plays a crucial role in the response to inflammatory signaling. Chromatin regulation responds to metabolic status and controls homeostasis. However, chromatin structure is also changed by aging. In this review, we discuss the functional contributions of chromatin regulation to inflammaging. Full article
(This article belongs to the Special Issue Targeting Inflammaging and Degeneration by Amino Acids)
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