Advanced Optical Fiber Sensors for Chemical and Biological Detection

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 4832

Special Issue Editors


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Guest Editor
Institute of Photonics Technology, Jinan University, Guangzhou 511443, China
Interests: optical fiber sensors; specialty optical fibers

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Guest Editor
State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China
Interests: plasmonic nano-optics devices; optical fiber biosensor; optical super-resolution imaging; single molecule detection and molecular detection
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Guest Editor
Institute of Applied Physics “Nello Carrara”, CNR-IFAC, Via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy
Interests: bio-photonics and biomedical optics; fiber optics; plasmonics; optical devices; detectors; sensors and sensing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The main topic of this Special Issue is the recent research and development related to advanced optical fiber sensors for rapid and disposable detection of specific chemicals and biomaterial for potential applications in the wide fields of life science, clinical diagnosis, food quality control, and environmental monitoring. For that, this Special Issue aims to gather original articles and reviews showing research advances in new mechanisms, materials, processes, innovative applications, new challenges, and future perspectives of optical fiber biochemical sensors.

Relevant topics include, but are not limited to:

  • Microstructured optical fiber sensors for chemical and biological sensing
  • Optical micro/nanofibers sensors for chemical and biological applications
  • Optical fiber grating based biochemical sensors
  • Fiber-optic surface plasmon resonance (SPR) sensors for biochemical analysis
  • Optical fiber-based surface-enhanced Raman spectroscopy (SERS) sensors
  • Stretchable optical fiber sensors for wearable motion monitoring and vital signs detection
  • Optical fiber lasers for biological applications
  • Lab on fibers
  • Optical fiber-based bioimaging

Dr. Kaiwei Li
Dr. Wenchao Zhou
Dr. Francesco Chiavaioli
Guest Editors

Manuscript Submission Information

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Keywords

  • optical fiber biosensor
  • optical fiber chemical sensor
  • specialty optical fiber
  • bioimaging
  • lab-on-fiber
  • SERS
  • SPR
  • fiber grating

Published Papers (2 papers)

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Research

12 pages, 6340 KiB  
Communication
A Multimode Microfiber Specklegram Biosensor for Measurement of CEACAM5 through AI Diagnosis
by Yuhui Liu, Weihao Lin, Fang Zhao, Yibin Liu, Junhui Sun, Jie Hu, Jialong Li, Jinna Chen, Xuming Zhang, Mang I. Vai, Perry Ping Shum and Liyang Shao
Biosensors 2024, 14(1), 57; https://doi.org/10.3390/bios14010057 - 22 Jan 2024
Cited by 1 | Viewed by 1286
Abstract
Carcinoembryonic antigen (CEACAM5), as a broad-spectrum tumor biomarker, plays a crucial role in analyzing the therapeutic efficacy and progression of cancer. Herein, we propose a novel biosensor based on specklegrams of tapered multimode fiber (MMF) and two-dimensional convolutional neural networks (2D-CNNs) for the [...] Read more.
Carcinoembryonic antigen (CEACAM5), as a broad-spectrum tumor biomarker, plays a crucial role in analyzing the therapeutic efficacy and progression of cancer. Herein, we propose a novel biosensor based on specklegrams of tapered multimode fiber (MMF) and two-dimensional convolutional neural networks (2D-CNNs) for the detection of CEACAM5. The microfiber is modified with CEA antibodies to specifically recognize antigens. The biosensor utilizes the interference effect of tapered MMF to generate highly sensitive specklegrams in response to different CEACAM5 concentrations. A zero mean normalized cross-correlation (ZNCC) function is explored to calculate the image matching degree of the specklegrams. Profiting from the extremely high detection limit of the speckle sensor, variations in the specklegrams of antibody concentrations from 1 to 1000 ng/mL are measured in the experiment. The surface sensitivity of the biosensor is 0.0012 (ng/mL)−1 within a range of 1 to 50 ng/mL. Moreover, a 2D-CNN was introduced to solve the problem of nonlinear detection surface sensitivity variation in a large dynamic range, and in the search for image features to improve evaluation accuracy, achieving more accurate CEACAM5 monitoring, with a maximum detection error of 0.358%. The proposed fiber specklegram biosensing scheme is easy to implement and has great potential in analyzing the postoperative condition of patients. Full article
(This article belongs to the Special Issue Advanced Optical Fiber Sensors for Chemical and Biological Detection)
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17 pages, 2950 KiB  
Article
Difunctional Hydrogel Optical Fiber Fluorescence Sensor for Continuous and Simultaneous Monitoring of Glucose and pH
by Yangjie Li, Site Luo, Yongqiang Gui, Xin Wang, Ziyuan Tian and Haihu Yu
Biosensors 2023, 13(2), 287; https://doi.org/10.3390/bios13020287 - 17 Feb 2023
Cited by 8 | Viewed by 2732
Abstract
It is significant for people with diabetes to know their body’s real-time glucose level, which can guide the diagnosis and treatment. Therefore, it is necessary to research continuous glucose monitoring (CGM) as it gives us real-time information about our health condition and its [...] Read more.
It is significant for people with diabetes to know their body’s real-time glucose level, which can guide the diagnosis and treatment. Therefore, it is necessary to research continuous glucose monitoring (CGM) as it gives us real-time information about our health condition and its dynamic changes. Here, we report a novel hydrogel optical fiber fluorescence sensor segmentally functionalized with fluorescein derivative and CdTe QDs/3-APBA, which can continuously monitor pH and glucose simultaneously. In the glucose detection section, the complexation of PBA and glucose will expand the local hydrogel and decrease the fluorescence of the quantum dots. The fluorescence can be transmitted to the detector by the hydrogel optical fiber in real time. As the complexation reaction and the swelling–deswelling of the hydrogel are all reversible, the dynamic change of glucose concentration can be monitored. For pH detection, the fluorescein attached to another segment of the hydrogel exhibits different protolytic forms when pH changes and the fluorescence changes correspondingly. The significance of pH detection is compensation for pH errors in glucose detection because the reaction between PBA and glucose is sensitive to pH. The emission peaks of the two detection units are 517 nm and 594 nm, respectively, so there is no signal interference between them. The sensor can continuously monitor glucose in 0–20 mM and pH in 5.4–7.8. The advantages of this sensor are multi-parameter simultaneous detection, transmission-detection integration, real-time dynamic detection, and good biocompatibility. Full article
(This article belongs to the Special Issue Advanced Optical Fiber Sensors for Chemical and Biological Detection)
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