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Biosensors
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Feature Review Papers for Biosensors
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Feature Review Papers for Biosensors

A special issue of Biosensors (ISSN 2079-6374).

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 27796

Special Issue Editor

Prof. Dr. Benoît Piro

E-Mail Website
Guest Editor
Chemistry Department, University Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR 7086 CNRS 15 rue J-A de Baïf, 75205 Paris, CEDEX 13, France
Interests: bioelectrochemistry; biosensors; bioelectronics; transistor; nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As Section Editor-in-Chief of Biosensors, I am pleased to announce this Special Issue, entitled “Feature Review Papers for Biosensors”. This Special Issue aims to collect high-quality review papers in the field of biosensors. We encourage researchers from various fields within the journal’s scope to contribute review papers that highlight the latest developments in their research field, or to invite relevant experts and colleagues to do so. The topic of this Special Issue includes, but is not limited to, the following topics:

  • Biosensor manufacturing and materials;
  • Biorecognition elements (antibody, enzymes, aptamer, nucleic acid, molecularly imprinted polymers) in biosensors;
  • Optical transducers and electrochemical transducers for biosensors;
  • Microfabrication and printing techniques in biosensors;
  • Wearable and implantable biosensors;
  • Development and application of biosensors in medicine, food industry, environmental monitoring, metabolism and agriculture.

Review manuscripts should comprise the front matter, literature review sections and the back matter. The template file can also be used to prepare the front and back matter of your review manuscript. It is not necessary to follow the remaining structure. Structured reviews and meta-analyses should use the same structure as research articles and ensure they conform to the PRISMA guidelines.

Prof. Dr. Benoît Piro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
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  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
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Further information on MDPI's Special Issue polices can be found here.

Published Papers (8 papers)

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Review

22 pages, 2299 KiB  
Review
Detection of Cannabinoids in Oral Fluid Specimens as the Preferred Biological Matrix for a Point-of-Care Biosensor Diagnostic Device
by Călin Trif, Dorin Harpaz, Evgeni Eltzov, Yardnapar Parcharoen, Chiravoot Pechyen and Robert S. Marks
Biosensors 2024, 14(3), 126; https://doi.org/10.3390/bios14030126 - 27 Feb 2024
Cited by 1 | Viewed by 2755
Abstract
An increasing number of countries have started to decriminalize or legalize the consumption of cannabis for recreational and medical purposes. The active ingredients in cannabis, termed cannabinoids, affect multiple functions in the human body, including coordination, motor skills, memory, response time to external [...] Read more.
An increasing number of countries have started to decriminalize or legalize the consumption of cannabis for recreational and medical purposes. The active ingredients in cannabis, termed cannabinoids, affect multiple functions in the human body, including coordination, motor skills, memory, response time to external stimuli, and even judgment. Cannabinoids are a unique class of terpeno-phenolic compounds, with 120 molecules discovered so far. There are certain situations when people under the influence of cannabis may be a risk to themselves or the public safety. Over the past two decades, there has been a growing research interest in detecting cannabinoids from various biological matrices. There is a need to develop a rapid, accurate, and reliable method of detecting cannabinoids in oral fluid as it can reveal the recent intake in comparison with urine specimens, which only show a history of consumption. Significant improvements are continuously made in the analytical formats of various technologies, mainly concerning improving their sensitivity, miniaturization, and making them more user-friendly. Additionally, sample collection and pretreatment have been extensively studied, and specific devices for collecting oral fluid specimens have been perfected to allow rapid and effective sample collection. This review presents the recent findings regarding the use of oral fluid specimens as the preferred biological matrix for cannabinoid detection in a point-of-care biosensor diagnostic device. A critical review is presented, discussing the findings from a collection of review and research articles, as well as publicly available data from companies that manufacture oral fluid screening devices. Firstly, the various conventional methods used to detect cannabinoids in biological matrices are presented. Secondly, the detection of cannabinoids using point-of-care biosensors is discussed, emphasizing oral fluid specimens. This review presents the current pressing technological challenges and highlights the gaps where new technological solutions can be implemented. Full article
(This article belongs to the Special Issue Feature Review Papers for Biosensors)
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20 pages, 4300 KiB  
Review
Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer’s Disease Drug Determination
by Alexey Ivanov, Rezeda Shamagsumova, Marina Larina and Gennady Evtugyn
Biosensors 2024, 14(2), 93; https://doi.org/10.3390/bios14020093 - 9 Feb 2024
Cited by 3 | Viewed by 2887
Abstract
Neurodegenerative diseases and Alzheimer’s disease (AD), as one of the most common causes of dementia, result in progressive losses of cholinergic neurons and a reduction in the presynaptic markers of the cholinergic system. These consequences can be compensated by the inhibition of acetylcholinesterase [...] Read more.
Neurodegenerative diseases and Alzheimer’s disease (AD), as one of the most common causes of dementia, result in progressive losses of cholinergic neurons and a reduction in the presynaptic markers of the cholinergic system. These consequences can be compensated by the inhibition of acetylcholinesterase (AChE) followed by a decrease in the rate of acetylcholine hydrolysis. For this reason, anticholinesterase drugs with reversible inhibition effects are applied for the administration of neurodegenerative diseases. Their overdosage, variation in efficiency and recommendation of an individual daily dose require simple and reliable measurement devices capable of the assessment of the drug concentration in biological fluids and medications. In this review, the performance of electrochemical biosensors utilizing immobilized cholinesterases is considered to show their advantages and drawbacks in the determination of anticholinesterase drugs. In addition, common drugs applied in treating neurodegenerative diseases are briefly characterized. The immobilization of enzymes, nature of the signal recorded and its dependence on the transducer modification are considered and the analytical characteristics of appropriate biosensors are summarized for donepezil, huperzine A, rivastigmine, eserine and galantamine as common anti-dementia drugs. Finally, the prospects for the application of AChE-based biosensors in clinical practice are discussed. Full article
(This article belongs to the Special Issue Feature Review Papers for Biosensors)
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18 pages, 4689 KiB  
Review
Surface Plasmon Resonance Biosensors: A Review of Molecular Imaging with High Spatial Resolution
by Jiying Xu, Pengfei Zhang and Yi Chen
Biosensors 2024, 14(2), 84; https://doi.org/10.3390/bios14020084 - 2 Feb 2024
Cited by 3 | Viewed by 4278
Abstract
Surface plasmon resonance (SPR) is a powerful tool for determining molecular interactions quantitatively. SPR imaging (SPRi) further improves the throughput of SPR technology and provides the spatially resolved capability for observing the molecular interaction dynamics in detail. SPRi is becoming more and more [...] Read more.
Surface plasmon resonance (SPR) is a powerful tool for determining molecular interactions quantitatively. SPR imaging (SPRi) further improves the throughput of SPR technology and provides the spatially resolved capability for observing the molecular interaction dynamics in detail. SPRi is becoming more and more popular in biological and chemical sensing and imaging. However, SPRi suffers from low spatial resolution due to the imperfect optical components and delocalized features of propagating surface plasmonic waves along the surface. Diverse kinds of approaches have been developed to improve the spatial resolution of SPRi, which have enormously impelled the development of the methodology and further extended its possible applications. In this minireview, we introduce the mechanisms for building a high-spatial-resolution SPRi system and present its experimental schemes from prism-coupled SPRi and SPR microscopy (SPRM) to surface plasmonic scattering microscopy (SPSM); summarize its exciting applications, including molecular interaction analysis, molecular imaging and profiling, tracking of single entities, and analysis of single cells; and discuss its challenges in recent decade as well as the promising future. Full article
(This article belongs to the Special Issue Feature Review Papers for Biosensors)
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14 pages, 4023 KiB  
Review
Recent Advances in Real-Time Label-Free Detection of Small Molecules
by Andy Chieng, Zijian Wan and Shaopeng Wang
Biosensors 2024, 14(2), 80; https://doi.org/10.3390/bios14020080 - 1 Feb 2024
Cited by 4 | Viewed by 3060
Abstract
The detection and analysis of small molecules, typically defined as molecules under 1000 Da, is of growing interest ranging from the development of small-molecule drugs and inhibitors to the sensing of toxins and biomarkers. However, due to challenges such as their small size [...] Read more.
The detection and analysis of small molecules, typically defined as molecules under 1000 Da, is of growing interest ranging from the development of small-molecule drugs and inhibitors to the sensing of toxins and biomarkers. However, due to challenges such as their small size and low mass, many biosensing technologies struggle to have the sensitivity and selectivity for the detection of small molecules. Notably, their small size limits the usage of labeled techniques that can change the properties of small-molecule analytes. Furthermore, the capability of real-time detection is highly desired for small-molecule biosensors’ application in diagnostics or screening. This review highlights recent advances in label-free real-time biosensing technologies utilizing different types of transducers to meet the growing demand for small-molecule detection. Full article
(This article belongs to the Special Issue Feature Review Papers for Biosensors)
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14 pages, 2719 KiB  
Review
Digital PCR for Single-Cell Analysis
by Weibo Fang, Xudong Liu, Mariam Maiga, Wenjian Cao, Ying Mu, Qiang Yan and Qiangyuan Zhu
Biosensors 2024, 14(2), 64; https://doi.org/10.3390/bios14020064 - 24 Jan 2024
Cited by 3 | Viewed by 3392
Abstract
Single-cell analysis provides an overwhelming strategy for revealing cellular heterogeneity and new perspectives for understanding the biological function and disease mechanism. Moreover, it promotes the basic and clinical research in many fields at a single-cell resolution. A digital polymerase chain reaction (dPCR) is [...] Read more.
Single-cell analysis provides an overwhelming strategy for revealing cellular heterogeneity and new perspectives for understanding the biological function and disease mechanism. Moreover, it promotes the basic and clinical research in many fields at a single-cell resolution. A digital polymerase chain reaction (dPCR) is an absolute quantitative analysis technology with high sensitivity and precision for DNA/RNA or protein. With the development of microfluidic technology, digital PCR has been used to achieve absolute quantification of single-cell gene expression and single-cell proteins. For single-cell specific-gene or -protein detection, digital PCR has shown great advantages. So, this review will introduce the significance and process of single-cell analysis, including single-cell isolation, single-cell lysis, and single-cell detection methods, mainly focusing on the microfluidic single-cell digital PCR technology and its biological application at a single-cell level. The challenges and opportunities for the development of single-cell digital PCR are also discussed. Full article
(This article belongs to the Special Issue Feature Review Papers for Biosensors)
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27 pages, 7733 KiB  
Review
Additive Manufacturing Applications in Biosensors Technologies
by Abraham Abbey Paul, Adedamola D. Aladese and Robert S. Marks
Biosensors 2024, 14(2), 60; https://doi.org/10.3390/bios14020060 - 23 Jan 2024
Cited by 4 | Viewed by 3478
Abstract
Three-dimensional (3D) printing technology, also known as additive manufacturing (AM), has emerged as an attractive state-of-the-art tool for precisely fabricating functional materials with complex geometries, championing several advancements in tissue engineering, regenerative medicine, and therapeutics. However, this technology has an untapped potential for [...] Read more.
Three-dimensional (3D) printing technology, also known as additive manufacturing (AM), has emerged as an attractive state-of-the-art tool for precisely fabricating functional materials with complex geometries, championing several advancements in tissue engineering, regenerative medicine, and therapeutics. However, this technology has an untapped potential for biotechnological applications, such as sensor and biosensor development. By exploring these avenues, the scope of 3D printing technology can be expanded and pave the way for groundbreaking innovations in the biotechnology field. Indeed, new printing materials and printers would offer new possibilities for seamlessly incorporating biological functionalities within the growing 3D scaffolds. Herein, we review the additive manufacturing applications in biosensor technologies with a particular emphasis on extrusion-based 3D printing modalities. We highlight the application of natural, synthetic, and composite biomaterials as 3D-printed soft hydrogels. Emphasis is placed on the approach by which the sensing molecules are introduced during the fabrication process. Finally, future perspectives are provided. Full article
(This article belongs to the Special Issue Feature Review Papers for Biosensors)
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22 pages, 4735 KiB  
Review
Emerging Biosensing Technologies towards Early Sepsis Diagnosis and Management
by Andrea Bonini, Angela Gilda Carota, Noemi Poma, Federico Maria Vivaldi, Denise Biagini, Daria Bottai, Alessio Lenzi, Arianna Tavanti, Fabio Di Francesco and Tommaso Lomonaco
Biosensors 2022, 12(10), 894; https://doi.org/10.3390/bios12100894 - 18 Oct 2022
Cited by 10 | Viewed by 3509
Abstract
Sepsis is defined as a systemic inflammatory dysfunction strictly associated with infectious diseases, which represents an important health issue whose incidence is continuously increasing worldwide. Nowadays, sepsis is considered as one of the main causes of death that mainly affects critically ill patients [...] Read more.
Sepsis is defined as a systemic inflammatory dysfunction strictly associated with infectious diseases, which represents an important health issue whose incidence is continuously increasing worldwide. Nowadays, sepsis is considered as one of the main causes of death that mainly affects critically ill patients in clinical settings, with a higher prevalence in low-income countries. Currently, sepsis management still represents an important challenge, since the use of traditional techniques for the diagnosis does not provide a rapid response, which is crucial for an effective infection management. Biosensing systems represent a valid alternative due to their characteristics such as low cost, portability, low response time, ease of use and suitability for point of care/need applications. This review provides an overview of the infectious agents associated with the development of sepsis and the host biomarkers suitable for diagnosis and prognosis. Special focus is given to the new emerging biosensing technologies using electrochemical and optical transduction techniques for sepsis diagnosis and management. Full article
(This article belongs to the Special Issue Feature Review Papers for Biosensors)
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42 pages, 7912 KiB  
Review
Biomechanical Sensing Using Gas Bubbles Oscillations in Liquids and Adjacent Technologies: Theory and Practical Applications
by Ivan S. Maksymov, Bui Quoc Huy Nguyen and Sergey A. Suslov
Biosensors 2022, 12(8), 624; https://doi.org/10.3390/bios12080624 - 10 Aug 2022
Cited by 7 | Viewed by 3242
Abstract
Gas bubbles present in liquids underpin many natural phenomena and human-developed technologies that improve the quality of life. Since all living organisms are predominantly made of water, they may also contain bubbles—introduced both naturally and artificially—that can serve as biomechanical sensors operating in [...] Read more.
Gas bubbles present in liquids underpin many natural phenomena and human-developed technologies that improve the quality of life. Since all living organisms are predominantly made of water, they may also contain bubbles—introduced both naturally and artificially—that can serve as biomechanical sensors operating in hard-to-reach places inside a living body and emitting signals that can be detected by common equipment used in ultrasound and photoacoustic imaging procedures. This kind of biosensor is the focus of the present article, where we critically review the emergent sensing technologies based on acoustically driven oscillations of bubbles in liquids and bodily fluids. This review is intended for a broad biosensing community and transdisciplinary researchers translating novel ideas from theory to experiment and then to practice. To this end, all discussions in this review are written in a language that is accessible to non-experts in specific fields of acoustics, fluid dynamics and acousto-optics. Full article
(This article belongs to the Special Issue Feature Review Papers for Biosensors)
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