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Biosensors
Special Issues
2D-Nanomaterials-Based Optical Biosensors
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2D-Nanomaterials-Based Optical Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 1131

Special Issue Editor

Dr. Leiming Wu

E-Mail Website
Guest Editor
School of Information Engineering, Guangdong University of Technology, Guangzhou, China
Interests: optical sensing technologies; 2D materials; surface plasmon resonance sensors

Special Issue Information

Dear Colleagues,

The proposed special issue aims to explore the cutting-edge advancements and applications of 2D nanomaterials in the development of optical biosensors. 2D nanomaterials, including graphene, transition metal dichalcogenides (TMDs), black phosphorus, and other 2D layered structures, have garnered significant interest due to their unique optical, electrical, and mechanical properties, making them ideal candidates for biosensing applications. These materials offer high surface-to-volume ratios, exceptional biocompatibility, and tunable properties, enabling innovative designs for highly sensitive and selective biosensors.

The special issue will encompass original research articles, reviews, and perspectives that highlight the latest developments in 2D nanomaterial-based optical biosensors. Topics of interest include, but are not limited to:

  1. Design and Fabrication of 2D Nanomaterial-Based Biosensors
  2. Surface Functionalization and Bioconjugation
  3. Optical Properties and Sensing Mechanisms
  4. 2D Nanomaterial-Based Plasmonic and Photonic Biosensors
  5. Biomedical and Environmental Applications
  6. Integration of 2D Nanomaterials in Sensor Platforms

The special issue aims to provide a comprehensive platform for researchers, scientists, and engineers to share their latest findings, exchange ideas, and contribute to the advancement of optical biosensing technologies leveraging 2D nanomaterials. By assembling high-quality contributions, this special issue will serve as a valuable resource for the biosensors community, fostering innovation and driving the field forward.

Dr. Leiming Wu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 2D nanomaterials
  • optical biosensors
  • graphene and its derivatives
  • transition metal dichalcogenides (TMDs)
  • black phosphorus biosensing
  • surface functionalization
  • plasmonic biosensors
  • photonic biosensors
  • biomedical applications

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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13 pages, 5150 KiB  
Article
Wide-Field High-Speed Scanning Acoustic/Photoacoustic Microscopy for Whole-Body Imaging of Small Animals
by Joongho Ahn, Hyoseok Choi, Seongjun Lim, Jin Young Kim and Jeongwoo Park
Biosensors 2025, 15(4), 200; https://doi.org/10.3390/bios15040200 - 21 Mar 2025
Viewed by 810
Abstract
Photoacoustic (PA) imaging combines optical contrast with ultrasound (US) detection, enabling high-resolution imaging of biological tissues with greater penetration depth than conventional optical techniques. Among its various implementations, photoacoustic microscopy (PAM) achieves micrometer-scale resolution by focusing laser excitation and detecting ultrasonic signals, allowing [...] Read more.
Photoacoustic (PA) imaging combines optical contrast with ultrasound (US) detection, enabling high-resolution imaging of biological tissues with greater penetration depth than conventional optical techniques. Among its various implementations, photoacoustic microscopy (PAM) achieves micrometer-scale resolution by focusing laser excitation and detecting ultrasonic signals, allowing for the detailed visualization of microvascular structures and fine tissue morphology. Over the last decade, PAM imaging speed has significantly increased by adopting PA scanners that steer optical and acoustic waves. However, these scanners must be placed after focusing optics to co-align the waves on a spot, which creates bent focal lines along the scanning direction and limits the scanning range. To achieve wide-field imaging, various image mosaic algorithms have been applied, but these methods require multiple manual operations, which take more time than the imaging itself. In this study, we developed a wide-field, high-speed scanning acoustic/photoacoustic microscopy (SA/PAM) system equipped with a transparent ultrasound transducer and a moving magnet linear stage, which eliminates the need for complex mosaic algorithms. This system enables wide-field imaging up to 50 × 50 mm2 while maintaining high lateral resolution, achieving an imaging speed of 50 Hz in a B-scan image. Through in vivo mouse US/PA imaging, the system demonstrated its capability to visualize blood vessels and organs across the whole body of small animals. These findings suggest that the SA/PAM system is a practical tool for biomedical research, allowing for efficient visualization of vascular networks and anatomical structures in various preclinical studies. Full article
(This article belongs to the Special Issue 2D-Nanomaterials-Based Optical Biosensors)
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