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Nanosensors for the Detection and Characterization of Food, Environmental and...
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Nanosensors for the Detection and Characterization of Food, Environmental and Medical Samples—2nd Edition

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 542

Special Issue Editor

Dr. Chenxu Yu

E-Mail Website
Guest Editor
Department of Agricultural and Biosystems Engineering, Iowa State University, Ames, IA, USA
Interests: biosensors; nanotechnology; spectroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The development of rapid-response biosensing technologies utilizing nanotechnology has become more relevant for furthering our understanding of biological phenomena related to food, agriculture, environment, and medicine. As we understand the molecular mechanisms that underlie the emergence and spread of pathogens/toxins and their consequent impact on our agricultural and food systems, environment and ecosystems, as well as public health, and gain insight into the molecular mechanisms of life itself, it becomes clear that the technologies to investigate, intervene, and mitigate need to be correspondingly small (i.e., within the realm of nanotechnology).

In this Special Issue, we will focus on research furthering our understanding of the interaction between nanoscale phenomena and various reagents, with a view to developing better nano-based biosensing technology. We will report novel devices and applications using nano-based approaches that can detect various pathogens and/or toxins and chemical pollutants faster and more accurately—especially in the areas of food, environmental and medical samples. This Special Issue will also discuss specificity and sensitivity challenges that still face biosensors applications, and hurdles to be overcome for more successful commercialization in various biosensor technologies. We would like to invite all researchers interested in these topics to join the discussion, and to show their work and findings to the scientific community to advance the welfare of human society. In light of the ongoing COVID-19 pandemic, progress in biosensor technologies is more important than ever before. We look forward to your contributions.

Dr. Chenxu Yu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • environmental
  • surveillance
  • pathogens
  • foods
  • medical
  • diagnosis
  • nanomaterials
  • optical
  • electrochemical
  • signal
  • processing
  • nanoimpact

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Published Papers (1 paper)

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Research

14 pages, 1793 KiB  
Article
A Metal–Organic Hybrid Composed of Dual Quenching Cofactors as a Nanoquencher for the Fluorescent Determination of Protease Caspase-3
by Fengli Gao, Lin Liu, Cancan He, Yong Chang and Weiqiang Wang
Biosensors 2025, 15(6), 354; https://doi.org/10.3390/bios15060354 - 4 Jun 2025
Viewed by 467
Abstract
Nanoquenchers with a single quenching cofactor exhibit limited fluorescence quenching efficiency. In this work, a metal–organic hybrid with dual quenching cofactors (Cu2+ and pyrroloquinoline quinone or PQQ) was prepared by metal-coordinated assembly and used as a nanoquencher for a protease assay with [...] Read more.
Nanoquenchers with a single quenching cofactor exhibit limited fluorescence quenching efficiency. In this work, a metal–organic hybrid with dual quenching cofactors (Cu2+ and pyrroloquinoline quinone or PQQ) was prepared by metal-coordinated assembly and used as a nanoquencher for a protease assay with enhanced quenching efficiency. The peptide substrate with an oligohistidine (His6) tag was labeled with a fluorophore. Caspase-3 was determined as a protease example. The substrate was attached onto the surface of the Cu-PQQ nanoquencher by a metal coordination interaction between the unsaturated Cu2+ on the nanoparticle surface and the His6 tag in the peptide. The cleavage of the peptide substrate by enzymatic hydrolysis led to the release of a fluorophore-conjugated segment from the nanoquencher surface, thus turning on the fluorescence. The nanoprobe was used to determine caspase-3 with a linear range of 0.01–5 ng/mL and a detection limit of 7 pg/mL. Furthermore, the method was used to evaluate inhibition efficiency and monitor drug-induced cell apoptosis. In contrast to other means of peptide immobilization, such as physical adsorption and covalent coupling, the strategy based on the metal coordination interaction is simple and powerful, thereby achieving assays of caspase-3 activity in lysates with a satisfactory result. The work should be valuable for the design of nanoquenchers with multiple quenching cofactors and the development of novel biosensors. Full article
(This article belongs to the Special Issue Nanosensors for the Detection and Characterization of Food, Environmental and Medical Samples—2nd Edition)
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