Electrochemical DNA Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1192

Special Issue Editors


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Guest Editor
College of Material Science and Engineering, Hainan University, Haikou 570228, China
Interests: biosensors; DNA nanostructure; nanomaterials; nanotechnology; electrochemical biosensors; biomaterials
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
Interests: biosensor; bioelectronics; biomaterials

Special Issue Information

Dear Colleagues,

Recently, DNA nanostructures have aroused tremendous concern as promising candidates in nanotechnology because of their excellent programming properties, remarkable controllability, and high precision, which has been extensively applied in the field of electrochemical bioanalysis. Unlike traditional DNA hybridization methods, DNA-based biosensors have higher sensitivity and lower manufacturing costs. Due to their unique advantages, DNA nanostructures can be designed to serve as universal units to form biosensors for the detection of many biomarkers. The preparation of multifunctional DNA nanostructures in a controlled and functionalized manner and the optimization of stability and reproducibility of DNA-based biosensors are the key to the development of DNA-based electrochemical biosensors. The merits of easy preparation, structural stability, mechanical rigidity, and high loading capacity make DNA nanostructure-based electrochemical biosensors a significant engineering paradigm for immobilizing numerous biomolecules.

The purpose of this Special Issue is to share new developments in the field of DNA electrochemical biosensors and the future prospects of this field. It also includes the research of nanomaterials and DNA-based photoelectrochemical biosensors.

Prof. Dr. Jinchun Tu
Prof. Dr. Minghui Yang
Guest Editors

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Keywords

  • biosensors
  • DNA nanostructure
  • nanomaterials
  • electrochemical biosensors
  • photoelectrochemical biosensors

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Published Papers (1 paper)

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Research

15 pages, 2384 KiB  
Article
Application of PS2M Aptamer as Receptor Layer for Electrochemical Detection of Lead Ions
by Izabela Zaras, Olga Kujawa, Marcin Olszewski and Marta Jarczewska
Biosensors 2025, 15(1), 59; https://doi.org/10.3390/bios15010059 - 17 Jan 2025
Viewed by 871
Abstract
Since lead can cause severe effects on living organisms’ health and life, the regular monitoring of Pb levels in water and soil is of particular significance. Recently, it was shown that lead ions can also be detected using affinity-based biosensors, namely, using aptamers [...] Read more.
Since lead can cause severe effects on living organisms’ health and life, the regular monitoring of Pb levels in water and soil is of particular significance. Recently, it was shown that lead ions can also be detected using affinity-based biosensors, namely, using aptamers as recognition elements. In most cases, thrombin binding aptamer (TBA) was utilized; however, there are more examples of DNA aptamers which could also serve that purpose. Herein, we present studies on the electrochemical detection of lead ions using PS2M aptamer, which contains several guanine nucleotides, as the receptor element. Firstly, the method of aptamer-based layer fabrication was optimized along with the choice of a redox active indicator, which was a source of current signal. The experiments revealed the possibility of lead ion detection from 50 to 600 nM, which covers the range below and above the maximum accepted limit stated by US EPA (72 nM). Moreover, the sensing layer exhibited high selectivity towards lead ions and was successfully applied both for the analysis of tap water spiked with Pb2+ ions and as a miniaturized sensor. Finally, stability and regeneration studies on the aptamer-based receptor layer were executed to confirm the utility of the elaborated tool. Full article
(This article belongs to the Special Issue Electrochemical DNA Biosensors)
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