Recent Developments in Micro/Nano Sensors for Biomedical Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 487

Special Issue Editors


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Guest Editor
School of Chemical Engineering and Australian Centre for Nanomedicine (ACN), The University of New South Wales, Sydney, NSW 2052, Australia
Interests: nanoparticles; sensors; drug delivery; biosensors

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Guest Editor
Nanophotonics and Advanced Materials Group, Faculty of Engineering, Universidad De La Salle Bajio, Campus Campestre, Leon 37150, Guanajuato, Mexico
Interests: synthesis of nanomaterials; device design and characterization; nanophotonics for biosensors and biomedicine; SERS; plasmonic; colorimetry; photo and radio luminescence; FRET; fluorescence lifetime; drug delivery; theranostic; PDT; PTT; food safety; POC devices; nanophotonics for solar cells and solid-state-lighting
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Special Issue Information

Dear Colleagues,

The integration of micro/nanosensor technologies in biomedical applications has rapidly emerged as a transformative research area, driving innovations in early diagnostics, real-time therapeutic monitoring, and personalized medicine. This Special Issue seeks to showcase recent advances and stimulate in-depth discussion on novel sensor designs, materials, and integration strategies to overcome current challenges in healthcare.

We invite submissions that address, but are not limited to, the following themes:

  • Innovative sensor architectures: designs that enhance sensitivity, selectivity, and miniaturization, including flexible and wearable biosensors.
  • Integration with microfluidics and lab-on-a-chip systems: approaches that enable efficient handling of biological samples and real-time analysis.
  • Advanced signal transduction and data processing: methods for converting biological signals into reliable, real-time quantifiable data, including integration with artificial intelligence, IoT, or machine learning.
  • Material innovations: exploration of novel biomaterials or nanomaterials to improve sensor performance and stability, particularly under clinical conditions.
  • Translational research: studies addressing the challenges of moving sensor technologies from proof-of-concept to clinical applications.
  • Sensor calibration and reliability: approaches to enhance reproducibility and robustness in clinical settings, including standardized testing protocols and long-term stability.
  • Integration with digital health platforms: combining micro/nanosensors with telemedicine, data analytics, and wireless communication to enable remote diagnostics and improved patient monitoring.

We welcome original research articles, comprehensive reviews, and communications that contribute to the development of robust biomedical sensing platforms that can be readily translated into clinical applications.

Dr. Federico Mazur
Prof. Dr. Elder De la Rosa Cruz
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micro/nanosensors
  • early diagnostics
  • lab-on-a-chip systems
  • microfluidics
  • real-time therapeutic monitoring
  • nanomaterials
  • clinical translation
  • digital health platforms
  • biomedical

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Published Papers (1 paper)

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Research

13 pages, 1977 KiB  
Article
Stamp-Imprinted Polymer EIS Biosensor for Amyloid-Beta Detection: A Novel Approach Towards Alzheimer’s Screening
by Chloé E. D. Davidson and Ravi Prakash
Biosensors 2025, 15(4), 228; https://doi.org/10.3390/bios15040228 - 3 Apr 2025
Viewed by 344
Abstract
Surface-imprinted polymers (SIPs) represent an exciting and cost-effective alternative to antibodies for electrochemical impedance spectroscopy (EIS)-based biosensing. They can be produced using simple printing techniques and have shown high efficacy in detecting large biomolecules and microorganisms. Stamp imprinting, a novel SIP method, creates [...] Read more.
Surface-imprinted polymers (SIPs) represent an exciting and cost-effective alternative to antibodies for electrochemical impedance spectroscopy (EIS)-based biosensing. They can be produced using simple printing techniques and have shown high efficacy in detecting large biomolecules and microorganisms. Stamp imprinting, a novel SIP method, creates the target analyte’s imprint using a soft lithography mask of the analyte matrix, thereby reducing material complexities and eliminating the need for cross-linking, which makes the process more scalable than the conventional SIPs. In this work, we demonstrate a stamp-imprinted EIS biosensor using a biocompatible polymer, polycaprolactone (PCL), for quantifying amyloid beta-42 (Aβ-42), a small peptide involved in the pathophysiology of Alzheimer’s disease. The evaluated SIP-EIS biosensors showed a detection limit close to 10 fg/mL, and a detection range covering the physiologically relevant concentration range of the analyte in blood serum (from 10 fg/mL to 10 μg/mL). The device sensitivity, which is found to be comparable to antibody-based EIS devices, demonstrates the potential of SIP-EIS biosensors as an exciting alternative to conventional antibody-based diagnostic approaches. We also evaluate the viability of analyzing these proteins in complex media, notably in the presence of serum albumin proteins, which cause biofouling and non-specific interactions. The combination of high sensitivity, selectivity, and ease of fabrication makes SIP-EIS biosensors particularly suited for portable and point-of-care applications. Full article
(This article belongs to the Special Issue Recent Developments in Micro/Nano Sensors for Biomedical Applications)
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