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Special Issue "Perspectives of Cyclodextrins"
Deadline for manuscript submissions: 15 March 2020.
Interests: Solid-solid reactions by mechanochemistry; Cyclodextrin inclusion compounds, Solubilisation of active pharmaceutical ingredients (APIs), Local therapeutic systems for osteosarcoma and osteoporosis, Antioxidant flavonoids and their Ru(II) complexes, Natural and metallo-organic compounds for cytotoxic and biocidal activities; Innovative medicines for leishmaniasis based on inorganic complexes and cyclodextrins
Cyclodextrins, since their first report in 1891 by Villiers, have already witnessed the turning of two centuries. In the 20th century, these molecules conquered many applications in varied areas such as pharmaceuticals, food, nutrition, cosmetics, crop science, catalysis and analytical chemistry. Now, in the 21st century, CDs are growing even further. A new generation of cyclodextrin scientists is pushing the boundaries of their applications to new and exciting fields. Some CDs are finding applications in medicine, not just as excipients but as novel medicines; the natural sustainability of CDs makes them ideal for bioremediation solutions and their unique host–guest chemistry allows them to be used in the retrieval of noble metals from waste slurry or to remediate water effluent from all sorts of contaminants. Progress in the field of materials science places cyclodextrins in a wide range of novel materials with boundless applications. This Special Issue will create a forum for the presentation of the most relevant progress made by the millennial generation of cyclodextrins, looking at the innovations of the last 19 years and projecting research into the future.
The international cyclodextrin scientific community is invited to present review articles addressing the innovative aspects of CDs in the 21st century, or alternatively, to present strongly original research papers reporting breakthrough applications of CDs.
I will be looking forward to reading your contributions.
Dr. Susana Santos Braga
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Host-guest chemistry
- Data processing and curing
- Healthcare applications
- Nutraceutical applications
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Tentative title: Inclusion of hydroxycinnamic acids in methylated cyclodextrins: effects on guest thermal stability and the nature of host-guest interactions.
Authors: Mino R Caira, Susan A Bourne, Lee E Hunt
Affiliations: Centre for Supramolecular Chemistry Research, Department of Chemistry, University of Cape Town, South Africa
Abstract: There is considerable interest in the use of cyclodextrins (CDs) to stabilise bioactive compounds derived from natural sources for potential medicinal and cosmeceutical applications. Hydroxycinnamic acids (HCAs) and their derivatives are significant in this context as they possess a broad spectrum of activities including e.g. antioxidant, antitumor, anti-inflammatory and other beneficial biological effects. Here we report the results of a study aimed at determining the effects on the thermal stabilities of the HCAs as a result of their encapsulation by the CDs and establishing the nature of the host-guest interactions. Following the isolation of eight distinct complexes, they were characterized by thermal analysis and X-ray diffraction methods. Full structural analyses revealed a variety of guest complexation modes ranging from full inclusion within the CD host cavities to unusual instances of complete guest exclusion. Occurrences of guest disorder and crystal isostructurality also featured in this series of complexes.