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Special Issue "Beta-Lactamases: Sequence, Structure, Function, and Inhibition"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 20 February 2020.
Beta-lactamases represent the most prevalent antibiotic resistance mechanism. Their existence has been known since before penicillin was introduced into the clinic. Their action continues to challenge antimicrobial chemotherapy by prompting the need for the continued discovery and development of new beta-lactam antibiotics and beta-lactamase inhibitors. Bacteria have effectively countered these drug development efforts through the evolution of their beta-lactamase genes, yielding enzymes with extended substrate spectra and resistance to existing beta-lactamase inhibitors. A recently emerging class of enzymes, the metallo-beta-lactamases, are notorious for having broad substrate spectra and there are currently no inhibitors against them available in the clinic. This Special Issue focuses on the biomolecular characteristics of beta-lactamases, including their sequence and evolution, structure and biophysical properties, their function, and ways to combat their action.
Dr. Peter Oelschlaeger
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- antibiotic resistance
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Tentative Title: Structural and Mechanistic Insights into β-Lactamase Inhibition
Author: Schofield C.J., Brem J., et al
Tentative Title: Mechanistic-based inhibitors of Metallo-beta-lactamases
Authors: Alejandro J. Vila, Antonela Palacios and Ma. Agustina Rossi
Tentative Title: Isothermal Titration Calorimetry (ITC) and β-Lactamase Inhibitors
Authors: Robert Bonomo, Chris Bethel and Magdalena Taracila
Affiliation: Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Tentative Title: The role of Ω–loop in the regulation of catalytic activity of class A beta-lactamases
Author: Alexey Egorov et al.
Affiliation: Moscow State University, Russia
Tentative Title: In silico identification and experimental validation of hits active against GES-5 beta-lactamase
Author: Raphael Klein, Donatella Tondi, Ruth Brenk
Affiliation: University of Bergen, Norway
Tentative Title: New class D enzyme
Author: Jean-Marie Frère et al.
Affiliation: Institut de Chimie B6a Sart-Tilman, Liège, Belgium
Tentative Title: Inhibition of beta-lactamses: a hope against the growing menace of multidruyge resistance
Author: Maria S. Ramirez, Robert A. Bonomo, Marcelo E. Tolmasky
Affiliation: California State University, Fullerton
Tentative Title: MBLinhibitors.com, a website resource offering information and expertise for the continued development of MBL inhibitors
Author: Michael W. Crowder, Zishuo Cheng, Caitlyn Thomas et al.
Affiliation: Department of Chemistry and Biochemistry, Miami University