Special Issue "Beta-Lactamases: Sequence, Structure, Function, and Inhibition"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (20 April 2020) | Viewed by 24729
Interests: antibiotic resistance; enzyme biochemistry; evolution and function of beta-lactamases; metallo-beta-lactamase inhibitors; Gram-negative infections and diabetes
Beta-lactamases represent the most prevalent antibiotic resistance mechanism. Their existence has been known since before penicillin was introduced into the clinic. Their action continues to challenge antimicrobial chemotherapy by prompting the need for the continued discovery and development of new beta-lactam antibiotics and beta-lactamase inhibitors. Bacteria have effectively countered these drug development efforts through the evolution of their beta-lactamase genes, yielding enzymes with extended substrate spectra and resistance to existing beta-lactamase inhibitors. A recently emerging class of enzymes, the metallo-beta-lactamases, are notorious for having broad substrate spectra and there are currently no inhibitors against them available in the clinic. This Special Issue focuses on the biomolecular characteristics of beta-lactamases, including their sequence and evolution, structure and biophysical properties, their function, and ways to combat their action.
Dr. Peter Oelschlaeger
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- antibiotic resistance