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MBLinhibitors.com, a Website Resource Offering Information and Expertise for the Continued Development of Metallo-β-Lactamase Inhibitors
Open AccessFeature PaperArticle

Interactions between Avibactam and Ceftazidime-Hydrolyzing Class D β-Lactamases

1
Centre for Protein Engineering, University of Liège, B 4000 Liège, Belgium
2
National Reference Laboratory for Monitoring of Antimicrobial Resistance in Gram-Negative Bacteria, CHU Dinant-Godinne, UCL Namur, B 5530 Yvoir, Belgium
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(3), 483; https://doi.org/10.3390/biom10030483
Received: 6 February 2020 / Revised: 10 March 2020 / Accepted: 15 March 2020 / Published: 23 March 2020
(This article belongs to the Special Issue Beta-Lactamases: Sequence, Structure, Function, and Inhibition)
Class D β-lactamases exhibit very heterogeneous hydrolysis activity spectra against the various types of clinically useful β-lactams. Similarly, and according to the available data, their sensitivities to inactivation by avibactam can vary by a factor of more than 100. In this paper, we performed a detailed kinetic study of the interactions between two ceftazidime-hydrolyzing OXA enzymes and showed that they were significantly more susceptible to avibactam than several other class D enzymes that do not hydrolyze ceftazidime. From a clinical point of view, this result is rather interesting if one considers that avibactam is often administered in combination with ceftazidime. View Full-Text
Keywords: class D β-lactamases; OXA-β-lactamases; OXA-24; OXA-163; OXA-427; avibactam; ceftazidime class D β-lactamases; OXA-β-lactamases; OXA-24; OXA-163; OXA-427; avibactam; ceftazidime
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MDPI and ACS Style

Frère, J.-M.; Bogaerts, P.; Huang, T.-D.; Stefanic, P.; Moray, J.; Bouillenne, F.; Brans, A. Interactions between Avibactam and Ceftazidime-Hydrolyzing Class D β-Lactamases. Biomolecules 2020, 10, 483. https://doi.org/10.3390/biom10030483

AMA Style

Frère J-M, Bogaerts P, Huang T-D, Stefanic P, Moray J, Bouillenne F, Brans A. Interactions between Avibactam and Ceftazidime-Hydrolyzing Class D β-Lactamases. Biomolecules. 2020; 10(3):483. https://doi.org/10.3390/biom10030483

Chicago/Turabian Style

Frère, Jean-Marie; Bogaerts, Pierre; Huang, Te-Din; Stefanic, Patrick; Moray, Joël; Bouillenne, Fabrice; Brans, Alain. 2020. "Interactions between Avibactam and Ceftazidime-Hydrolyzing Class D β-Lactamases" Biomolecules 10, no. 3: 483. https://doi.org/10.3390/biom10030483

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