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The Future of Protein Secondary Structure Prediction Was Invented by Oleg Ptitsyn

1
Centre for Molecular and Biomolecular Informatics (CMBI), Radboudumc, 6525 GA Nijmegen, The Netherlands
2
Bio-Prodict, 6511 AA Nijmegen, The Netherlands
3
Baco Institute of Protein Science (BIPS), Mindoro 5201, Philippines
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2020, 10(6), 910; https://doi.org/10.3390/biom10060910
Received: 15 May 2020 / Accepted: 2 June 2020 / Published: 16 June 2020
When Oleg Ptitsyn and his group published the first secondary structure prediction for a protein sequence, they started a research field that is still active today. Oleg Ptitsyn combined fundamental rules of physics with human understanding of protein structures. Most followers in this field, however, use machine learning methods and aim at the highest (average) percentage correctly predicted residues in a set of proteins that were not used to train the prediction method. We show that one single method is unlikely to predict the secondary structure of all protein sequences, with the exception, perhaps, of future deep learning methods based on very large neural networks, and we suggest that some concepts pioneered by Oleg Ptitsyn and his group in the 70s of the previous century likely are today’s best way forward in the protein secondary structure prediction field. View Full-Text
Keywords: Oleg Ptitsyn; secondary structure prediction Oleg Ptitsyn; secondary structure prediction
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Rademaker, D.; van Dijk, J.; Titulaer, W.; Lange, J.; Vriend, G.; Xue, L. The Future of Protein Secondary Structure Prediction Was Invented by Oleg Ptitsyn. Biomolecules 2020, 10, 910.

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