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Interface of Phospholipase Activity, Immune Cell Function, and Atherosclerosis

Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2020, 10(10), 1449; https://doi.org/10.3390/biom10101449
Received: 12 September 2020 / Revised: 30 September 2020 / Accepted: 13 October 2020 / Published: 15 October 2020
(This article belongs to the Special Issue Phospholipases: From Structure to Biological Function)
Phospholipases are a family of lipid-altering enzymes that can either reduce or increase bioactive lipid levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote G-coupled-protein activity, and modulate membrane fluidity, which mediates cellular function. Phospholipases and the bioactive lipids they produce are important regulators of immune cell activity, dictating both pro-inflammatory and pro-resolving activity. During atherosclerosis, pro-inflammatory and pro-resolving activities govern atherosclerosis progression and regression, respectively. This review will look at the interface of phospholipase activity, immune cell function, and atherosclerosis. View Full-Text
Keywords: atherosclerosis; phospholipases; macrophages; T cells; lipins atherosclerosis; phospholipases; macrophages; T cells; lipins
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Schilke, R.M.; Blackburn, C.M.R.; Bamgbose, T.T.; Woolard, M.D. Interface of Phospholipase Activity, Immune Cell Function, and Atherosclerosis. Biomolecules 2020, 10, 1449.

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