Next Article in Journal
Assessment of Fibrinogen Macromolecules Interaction with Red Blood Cells Membrane by Means of Laser Aggregometry, Flow Cytometry, and Optical Tweezers Combined with Microfluidics
Next Article in Special Issue
Metabolic Effects of Selective Deletion of Group VIA Phospholipase A2 from Macrophages or Pancreatic Islet Beta-Cells
Previous Article in Journal
Genetic Alterations in the INK4a/ARF Locus: Effects on Melanoma Development and Progression
Previous Article in Special Issue
cPLA2α Enzyme Inhibition Attenuates Inflammation and Keratinocyte Proliferation
Open AccessReview

Interface of Phospholipase Activity, Immune Cell Function, and Atherosclerosis

Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2020, 10(10), 1449;
Received: 12 September 2020 / Revised: 30 September 2020 / Accepted: 13 October 2020 / Published: 15 October 2020
(This article belongs to the Special Issue Phospholipases: From Structure to Biological Function)
Phospholipases are a family of lipid-altering enzymes that can either reduce or increase bioactive lipid levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote G-coupled-protein activity, and modulate membrane fluidity, which mediates cellular function. Phospholipases and the bioactive lipids they produce are important regulators of immune cell activity, dictating both pro-inflammatory and pro-resolving activity. During atherosclerosis, pro-inflammatory and pro-resolving activities govern atherosclerosis progression and regression, respectively. This review will look at the interface of phospholipase activity, immune cell function, and atherosclerosis. View Full-Text
Keywords: atherosclerosis; phospholipases; macrophages; T cells; lipins atherosclerosis; phospholipases; macrophages; T cells; lipins
Show Figures

Figure 1

MDPI and ACS Style

Schilke, R.M.; Blackburn, C.M.R.; Bamgbose, T.T.; Woolard, M.D. Interface of Phospholipase Activity, Immune Cell Function, and Atherosclerosis. Biomolecules 2020, 10, 1449.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop