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Open AccessFeature PaperReview

Lipid Phosphate Phosphatases and Cancer

by Xiaoyun Tang 1,2 and David N. Brindley 1,2,*
Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2S2, Canada
Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(9), 1263;
Received: 12 August 2020 / Revised: 28 August 2020 / Accepted: 30 August 2020 / Published: 2 September 2020
(This article belongs to the Special Issue Phospholipases: From Structure to Biological Function)
Lipid phosphate phosphatases (LPPs) are a group of three enzymes (LPP1–3) that belong to a phospholipid phosphatase (PLPP) family. The LPPs dephosphorylate a wide spectrum of bioactive lipid phosphates, among which lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P) are two important extracellular signaling molecules. The LPPs are integral membrane proteins, which are localized on plasma membranes and intracellular membranes, including the endoplasmic reticulum and Golgi network. LPPs regulate signaling transduction in cancer cells and demonstrate different effects in cancer progression through the breakdown of extracellular LPA and S1P and other intracellular substrates. This review is intended to summarize an up-to-date understanding about the functions of LPPs in cancers. View Full-Text
Keywords: PAP-2; autotaxin; lysophosphatidate; G protein-coupled receptor PAP-2; autotaxin; lysophosphatidate; G protein-coupled receptor
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Tang, X.; Brindley, D.N. Lipid Phosphate Phosphatases and Cancer. Biomolecules 2020, 10, 1263.

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