Special Issue "Galectins: their Network and Roles in Infection/Immunity/Tumor Growth Control"

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Pathology".

Deadline for manuscript submissions: 31 March 2020.

Special Issue Editor

Prof. Toshio Hattori
E-Mail Website
Guest Editor
Kibi International University, Takahashi, Japan
Tel. 0866229454
Interests: infectious diseases; tuberculosis; retrovirus; dengue; osteopontin; galectin-9
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Glycans are essential to proper animal development and cellular differentiation, but they are also involved in many pathogenic processes, including inflammation, tumor, microbial, and parasitic pathogenesis. Glycan-binding proteins (GBPs or lectins) are expressed by all types of cells and a growing class of bio-active proteins. The focus of this Special Issue is galectin, a lectin family that is defined by the presence of a highly conserved ~130 amino acid carbohydrate recognition domain (CRD) that recognizes β-galactoside residues . Evolutionarily, galectins are also conserved in many phyla, including birds, amphibians, fish, nematodea, drosophila, sponges, and fungi. There are 15 different subtypes in this family that have been identified in a wide variety of human cells and tissues. Galectins are stored in the cytoplasm of many types of immune and stromal cells that occur at the entry sites of pathogenic micro-organisms, including fibroblasts, keratinocytes, endothelial cells, and mucosal membrane epithelial cells. Despite the highly conserved nature of galectin CRDs, subtle yet significant differences occur in the binding affinity between different members of the galectin protein family. Galectins are present inside the cytosol, close to the cellular membrane, or in the extracellular space, showing that they are probably released via non-classical secretory pathways and are involved in the control of RNA splicing, intracellular regulation of apoptotic signaling, and endocytic machinery and trafficking.  Galectins are also released from injured cells and express a variety of activities under pathological conditions. This Special Issue aims to present studies that describe novel aspects of galectins.

Prof. Toshio Hattori
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • infectious disease
  • cancer
  • inflammation
  • apoptosis

Published Papers

This special issue is now open for submission.
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