Special Issue "Zinc and Copper in Human Health and Disease"
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 28054
Interests: studying a rare genetic disorder known as Mucolipidosis type IV (MLIV) using molecular biology, cell biology, proteomics, and next- generation sequencing (transcriptomics); mechanisms of zinc transport (SLC30, SLC39, TMEM163) and their protein interactome; zinc neurobiology; TRP ion channels; Involvement of transmembrane (TMEM) proteins in cancer pathology (TMEM163, TMEM176A, TMEM176B)
Interests: copper components of blood plasma and their functions and regulation in health, gestation, infancy and disease; mechanisms of copper uptake and excretion in mammals; interactions between iron and copper transport; iron mobilization from ferritin
Interests: bacterial virulence; antibiotic resistance
Special Issues, Collections and Topics in MDPI journals
Trace elements such as zinc and copper are critical to the proper functioning of many human proteins. Zinc and copper are essential co-factors for large variety of enzymes in all areas of metabolism. Zinc however, being redox-inert (in comparison to copper), also serves in a structural capacity for a number of metalloproteins. Abnormal zinc or copper metabolism has been implicated in various human ailments, ranging from acrodermatitis enteropathica, cancer, and diabetes, to several neurodegenerative as well as metal deficiency and overload diseases (Alzheimer’s, Parkinson’s, Menkes, Wilson disease, and Mucolipidosis type IV). Normal function and health depend on their cellular concentrations being tightly controlled, which is determined by metal-binding proteins and transporters in membranes and body fluids.
We invite investigators in the field to submit original research or review articles converging on the importance of zinc and/or copper in human health, and their potential contributions to treatments of multiple disorders that include malignancies, neurodegeneration, as well as viral and bacterial infections. We also welcome research studying the pathological effects of zinc or copper dyshomeostasis and the development of possible disease therapeutics using metalloproteins, transporters, or metal-specific drug chelators.
Prof. Dr. Math P. Cuajungco
Prof. Dr. Maria C. Linder
Prof. Dr. Marcelo E. Tolmasky
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Antibiotic resistance
- Copper in disease
- Copper chelation
- Copper transporters
- Zinc chelation
- Zinc transporters