Special Issue "Protein–Ligand Interactions: Target Identification and Drug Discovery 2.0"
Deadline for manuscript submissions: 30 April 2023 | Viewed by 5241
Interests: oxidative stress; cellular biochemistry; signal transduction; protein–ligand interaction; bioactive compounds
Special Issues, Collections and Topics in MDPI journals
Special Issue in International Journal of Molecular Sciences: Protein–Ligand Interactions: Deciphering the Molecular Targets and the Mechanisms of Action of Drugs and Natural Compounds 2.0
Special Issue in Biomedicines: Protein–Ligand Interactions: Target Identification and Drug Discovery
Special Issue in Biomedicines: Editorial Board Members’ Collection Series in Drug Discovery
Special Issue in International Journal of Molecular Sciences: Protein-Protein and Protein-DNA Interactions in Drug Discovery
Bioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as the identification of active ingredients from traditional medicine or by serendipitous discovery. The development of novel therapeutic strategies requires a deep knowledge of not only the molecular processes and the cellular pathways involved in each pathological condition and disease, but also the specific protein targets and the effects of drug binding on protein conformation and activity. The understanding of how drugs can modify and modulate specific cellular pathways and functions will be helpful during the process of drug development and clinical trials.
For many bioactive compounds, there is a lack of knowledge of the specific molecular targets involved, the effects of these substances on protein structure, and how they can modulate different cellular pathways and functions. This Special Issue focuses on recent studies aiming to investigate protein–ligand interactions with a special aim of elucidating the molecular modes of action of drugs as well as natural bioactive compounds. Studies highlighting information on target proteins and how interactions with a drug may affect a protein’s structure and biological activity will be welcome. Computational results accompanied by validation experiments are also sought after. This information will help to elucidate the molecular basis for many drugs’ activities and the development of new drugs.
Prof. Dr. Fabio Altieri
Manuscript Submission Information
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