Nonsense-Mediated mRNA Decay: From Molecular Mechanism to Therapeutic Perspectives 2.0
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Gene and Cell Therapy".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 4318
Special Issue Editor
Interests: mRNA; nonsense mutations
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Quality-control mechanisms ensure the correct expression of the information contained in a gene. The most-studied quality-control mechanism is certainly that responsible for eliminating mRNAs carrying a premature stop codon, called nonsense-mediated mRNA decay (NMD). NMD was first described in yeast in 1979 by Régine Losson and François Lacroute, and it has only been 40 years since NMD was also observed in human cells by Lynne Maquat and colleagues. Since then, the molecular mechanism has been studied in detail, from the identification of the main factors involved in this mechanism to its complex connections with other cellular metabolic pathways. The interest in NMD also comes from the fact that its role as a cell cleaner of mRNAs carrying premature stop codons links it to the origin of approximately 10% of cases of genetic diseases. Some groups therefore seek to inhibit it, while others rather try to activate it, by means of various molecules in order to propose new therapeutic approaches for the treatment of genetic diseases, as well as to study the mechanism of NMD in a particular configuration. Much remains to be learned about this mechanism for understanding the chains of reactions and interactions that lead to letting an mRNA continue its translation or, on the contrary, very quickly degrading an mRNA carrying a premature stop codon. A molecular understanding of this mechanism is necessary if we want to be able to control it and thus manage the fate of certain mRNAs, whether pathological or not. This Special Issue aims to provide up-to-date molecular insight into the nonsense-mediated mRNA decay mechanism, its regulation and its involvement in various pathologies.
Dr. Fabrice Lejeune
Guest Editor
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Keywords
- premature termination codon
- nonsense-mediated mRNA decay
- mRNA decay
- UPF proteins
- SMG proteins
- exon junction complex
- p-bodies
- pioneer round of translation
- gene expression and regulation
- human genetic diseases
