Developing New Agents for Inflammation and Obesity, and Its Related Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 4367

Special Issue Editor


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Guest Editor
Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea
Interests: insulin resistance; inflammation; macrophage; obesity-induced insulin resistance; developing new agents for obesity, insulin resistance and metabolic syndrome

Special Issue Information

Dear Colleagues,

The obesity epidemic has become an alarming, substantial public health crisis. Obesity is widely accepted as an inflammatory disease, and obesity-related diseases, such as dyslipidemia, steatohepatitis, type 2 diabetes mellitus, and cardiovascular diseases, share common characteristics of inflammation. Based on this knowledge, inflammation has become a major target of new drugs to fight obesity and obesity-related diseases.

This Special Issue aims to focus on recent advances in clinical or preclinical research of obesity and inflammation, and in developing new agents, including natural products, for inflammation and obesity, and its related disease. We also welcome all kinds of research describing obesity and inflammation-related disease, as well as natural compounds.

Dr. Byung-Cheol Lee
Guest Editor

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Keywords

  • obesity
  • inflammation
  • drug development
  • natural compounds
  • bioactive peptides

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Published Papers (1 paper)

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Research

13 pages, 4322 KiB  
Article
Cellular and Molecular Mechanisms and Effects of Berberine on Obesity-Induced Inflammation
by Ji-Won Noh, Min-Soo Jun, Hee-Kwon Yang and Byung-Cheol Lee
Biomedicines 2022, 10(7), 1739; https://doi.org/10.3390/biomedicines10071739 - 19 Jul 2022
Cited by 18 | Viewed by 3739
Abstract
Obesity represents chronic low-grade inflammation that precipitates type 2 diabetes, cardiovascular disease, and cancer. Berberine (BBR) has been reported to exert anti-obesity and anti-inflammatory benefits. We aimed to demonstrate the underlying immune-modulating mechanisms of anti-obesity effects of BBR. First, we performed in silico [...] Read more.
Obesity represents chronic low-grade inflammation that precipitates type 2 diabetes, cardiovascular disease, and cancer. Berberine (BBR) has been reported to exert anti-obesity and anti-inflammatory benefits. We aimed to demonstrate the underlying immune-modulating mechanisms of anti-obesity effects of BBR. First, we performed in silico study to identify therapeutic targets, describe potential pathways, and simulate BBR docking at M1 and M2 adipose tissue macrophages (ATMs), tumor necrosis factor-α (TNF-α), C-C motif chemokine ligand 2 (CCL2), CCL4, CCL5, and C-X-C motif chemokine receptor 4 (CXCR4). Next, in vivo, we divided 20 C58BL/6 mice into four groups: normal chow, control (high fat diet (HFD)), HFD + BBR 100 mg/kg, and HFD + metformin (MET) 200 mg/kg. We evaluated body weight, organ weight, fat area in tissues, oral glucose and fat tolerance tests, HOMA-IR, serum lipids levels, population changes in ATMs, M1 and M2 subsets, and gene expression of TNF-α, CCL2, CCL3, CCL5, and CXCR4. BBR significantly reduced body weight, adipocyte size, fat deposition in the liver, HOMA-IR, triglycerides, free fatty acids, ATM infiltration, all assessed gene expression, and enhanced the CD206+ M2 ATMs population. In conclusion, BBR treats obesity and its associated metabolic dysfunctions, by modulating ATM recruitment and polarization via chemotaxis inhibition. Full article
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