Drug Delivery across the Blood-Brain Barrier for the Treatment of Brain Diseases

Dear Colleagues,

Blood-brain barrier (BBB) studies have greatly accelerated progress in precision medicine for brain diseases. However, much remains to be elucidated. The role of the BBB in the onset and progression of brain diseases has been only been partially clarified. Studies on BBB biology have not only provided insights into the mechanisms underlying its tight regulation of molecule traffic between blood and neural tissue but also suggested that the nature, structure, and functions of the BBB are even more complex than previously considered. Our knowledge in the drug delivery research field has been greatly improved by BBB studies. In addition, new groundbreaking technologies, such as 3D live imaging and in vitro fluidodynamic cell culture systems, have greatly expanded our knowledge in this field, permitting researchers to study and demonstrate, at least in part, the involvement of the BBB in the main brain diseases. This Special Issue focuses on recent advances in the discovery, characterization, translation, and application of drug delivery across the BBB. The aim is to stimulate research interest in this field toward both improving the existing while developing new strategies for efficient drug delivery across BBB, which will be useful for the treatment of brain diseases.

Prof. Salvatore Valiante
Guest Editor
Dr. Annarita Falanga
Co-Guest Editor

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