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Biomedicines
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Genetic and Epigenetics of Kidney Development: Pathologies of Renal Anomalies...
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Genetic and Epigenetics of Kidney Development: Pathologies of Renal Anomalies and Kidney Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular Genetics and Genetic Diseases".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 3643

Special Issue Editor

Dr. Hongbing Liu

E-Mail Website
Guest Editor
Department of Pediatric Nephrology, Tulane University School of Medicine, New Orleans, LA 70112, USA
Interests: epigenetic regulation of kidney development and diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Congenital anomalies of the kidney and urinary tract (CAKUT) contribute significantly to renal failure and predispose to the development of kidney disease. Genetic and epigenetic regulations are very important for kidney formation and the development of kidney disease. Thus, there is a critical need to fully understand the molecular mechanisms underlying kidney development and diseases to provide a strong conceptual framework for the development of therapeutic interventions to prevent and treat CAJUT and progressive kidney disease.

Dr. Hongbing Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genetics
  • epigenetics
  • CAKUT
  • kidney development
  • kidney diseases

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Published Papers (2 papers)

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Review

38 pages, 531 KiB  
Review
Epigenetics of Hypertensive Nephropathy
by Yize Zhang, Hamidreza Arzaghi, Zhehan Ma, Yasmin Roye and Samira Musah
Biomedicines 2024, 12(11), 2622; https://doi.org/10.3390/biomedicines12112622 - 16 Nov 2024
Viewed by 1575
Abstract
Hypertensive nephropathy (HN) is a leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD), contributing to significant morbidity, mortality, and rising healthcare costs. In this review article, we explore the role of epigenetic mechanisms in HN progression and their potential [...] Read more.
Hypertensive nephropathy (HN) is a leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD), contributing to significant morbidity, mortality, and rising healthcare costs. In this review article, we explore the role of epigenetic mechanisms in HN progression and their potential therapeutic implications. We begin by examining key epigenetic modifications—DNA methylation, histone modifications, and non-coding RNAs—observed in kidney disease. Next, we discuss the underlying pathophysiology of HN and highlight current in vitro and in vivo models used to study the condition. Finally, we compare various types of HN-induced renal injury and their associated epigenetic mechanisms with those observed in other kidney injury models, drawing inferences on potential epigenetic therapies for HN. The information gathered in this work indicate that epigenetic mechanisms can drive the progression of HN by regulating key molecular signaling pathways involved in renal damage and fibrosis. The limitations of Renin–Angiotensin–Aldosterone System (RAAS) inhibitors underscore the need for alternative treatments targeting epigenetic pathways. This review emphasizes the importance of further research into the epigenetic regulation of HN to develop more effective therapies and preventive strategies. Identifying novel epigenetic markers could provide new therapeutic opportunities for managing CKD and reducing the burden of ESRD. Full article
(This article belongs to the Special Issue Genetic and Epigenetics of Kidney Development: Pathologies of Renal Anomalies and Kidney Diseases)
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17 pages, 514 KiB  
Review
The Impact of Autosomal Dominant Polycystic Kidney Disease in Children: A Nephrological, Nutritional, and Psychological Point of View
by Matteo Guarnaroli, Flavia Padoan, Cristiano Fava, Maria Giulia Benetti, Milena Brugnara, Angelo Pietrobelli, Giorgio Piacentini and Luca Pecoraro
Biomedicines 2024, 12(8), 1823; https://doi.org/10.3390/biomedicines12081823 - 12 Aug 2024
Cited by 1 | Viewed by 1534
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder characterized by the formation of numerous fluid-filled cysts in the kidneys, leading to progressive renal failure and various extrarenal complications, including hypertension. This review explores the genetic basis of ADPKD, including emerging evidence [...] Read more.
Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder characterized by the formation of numerous fluid-filled cysts in the kidneys, leading to progressive renal failure and various extrarenal complications, including hypertension. This review explores the genetic basis of ADPKD, including emerging evidence of epigenetic mechanisms in modulating gene expression and disease progression in ADPKD. Furthermore, it proposes to examine the pathological characteristics of this condition at the nephrological, cardiovascular, nutritional, and psychological levels, emphasizing that the follow-up of patients with ADPKD should be multidisciplinary from a young pediatric age. Full article
(This article belongs to the Special Issue Genetic and Epigenetics of Kidney Development: Pathologies of Renal Anomalies and Kidney Diseases)
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