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Biomedicines
Special Issues
Application of Biomedical Materials in Cancer Therapy
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Application of Biomedical Materials in Cancer Therapy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 680

Special Issue Editor

Dr. Rui Sang

E-Mail Website
Guest Editor
Graduate School of Biomedical Engineering, Faculty of Engineering, University of New South Wales, Sydney, NSW 2052, Australia
Interests: drug delivery system; targeted therapy; biometiarial for cancer therapy; X-ray triggerable photodynamic therapy; CRISPR technology for cancer dignosis and therapy

Special Issue Information

Dear Colleagues,

The Special Issue on the "Application of Biomedical Materials in Cancer Therapy" aims to explore the latest innovations and applications of biomedical materials to enhance the diagnosis and treatment of cancer. This interdisciplinary field encompasses a wide range of topics, including the design and synthesis of novel biomaterials, advanced drug delivery systems, and cutting-edge imaging agents. Additionally, it covers the development of scaffolds for tissue engineering and regenerative medicine, which are pivotal in reconstructive surgeries following tumor removal.

We aim to showcase research that explores the molecular mechanisms by which these materials interact with cancer cells, the tumor microenvironment, and the immune system. The Issue will also delve into the challenges and solutions related to the biocompatibility, biodegradability, and targeted delivery of therapeutic agents. By featuring a diverse collection of original research, comprehensive reviews, and case studies, this Special Issue aspires to provide a platform for researchers, clinicians, and industry experts to share their findings, discuss emerging trends, and contribute to the advancement of cancer therapy.

Submissions that demonstrate significant advancements in improving therapeutic efficacy, minimizing adverse effects, and enabling personalized treatment approaches are highly encouraged. We invite contributions that push the boundaries of conventional cancer therapies and offer new hope in the ongoing battle against this formidable disease.

Dr. Rui Sang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical materials
  • cancer therapy
  • drug delivery systems
  • biomaterials synthesis
  • imaging agents
  • tissue engineering
  • regenerative medicine
  • tumor microenvironment
  • targeted therapy
  • biocompatibility

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

18 pages, 4103 KiB  
Article
Dual-Emitting Molecularly Imprinted Nanopolymers for the Detection of CA19-9
by Eduarda Rodrigues, Ana Xu, Rafael C. Castro, David S. M. Ribeiro, João L. M. Santos and Ana Margarida L. Piloto
Biomedicines 2025, 13(7), 1629; https://doi.org/10.3390/biomedicines13071629 - 3 Jul 2025
Viewed by 364
Abstract
Background/Objectives: Carbohydrate antigen 19-9 (CA19-9) is a clinically established biomarker primarily used for monitoring disease progression and recurrence in pancreatic and gastrointestinal cancers. Accurate and continuous quantification of CA19-9 in patient samples is critical for effective clinical management. This study aimed to develop [...] Read more.
Background/Objectives: Carbohydrate antigen 19-9 (CA19-9) is a clinically established biomarker primarily used for monitoring disease progression and recurrence in pancreatic and gastrointestinal cancers. Accurate and continuous quantification of CA19-9 in patient samples is critical for effective clinical management. This study aimed to develop dual-emitting molecularly imprinted nanopolymers (dual@nanoMIPs) for ratiometric and reliable detection of CA19-9 in serum. Methods: Dual-emitting nanoMIPs were synthesized via a one-step molecular imprinting process, incorporating both blue-emitting carbon dots (b-CDs) as internal reference fluorophores and yellow-emitting quantum dots (y-QDs) as responsive probes. The CA19-9 template was embedded into the polymer matrix to create specific recognition sites. Fluorescence measurements were carried out under 365 nm excitation in 1% human serum diluted in phosphate-buffered saline (PBS). Results: The dual@nanoMIPs exhibited a ratiometric fluorescence response upon CA19-9 binding, characterized by the emission quenching of the y-QDs at 575 nm, while the b-CDs emission remained stable at 467 nm. The fluorescence shift observed in the RGB coordinates from yellow to green in the concentration range of CA19-9 tested, improved quantification accuracy by compensating for matrix effects in serum. A linear detection range was achieved from 4.98 × 10−3 to 8.39 × 102 U mL−1 in serum samples, with high specificity and reproducibility. Conclusions: The dual@nanoMIPs developed in this work enable a stable, sensitive, and specific detection of CA19-9 in minimally processed serum, offering a promising tool for longitudinal monitoring of cancer patients. Its ratiometric fluorescence design enhances reliability, supporting clinical decision-making in the follow-up of pancreatic cancer. Full article
(This article belongs to the Special Issue Application of Biomedical Materials in Cancer Therapy)
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