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Biomedicines
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State-of-the-Art Dermatology in Spain
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State-of-the-Art Dermatology in Spain

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (30 September 2025) | Viewed by 3652

Special Issue Editors

Dr. Francisco José Navarro-Triviño

E-Mail Website
Guest Editor
Contact Eczema and Immunoallergic Diseases, Dermatology Department, Hospital Universitario San Cecilio, Avda. del Conocimiento s/n, 18016 Granada, Spain
Interests: mechanisms of immunopathology in allergic contact dermatitis; new diagnostic approaches for ACD; emerging allergens and their clinical relevance; genetic and epigenetic factors influencing susceptibility to ACD; comorbidities associated with ACD (e.g., atopic dermatitis, psoriasis); role of microbiome in ACD pathogenesis; advances in patch testing techniques and interpretation; occupational and environmental risk factors for ACD; innovations in prevention and management strategies; biomarkers for prognosis and monitoring in ACD; impact of ACD on quality of life and psychosocial health; emerging therapeutic targets and novel treatments
Special Issues, Collections and Topics in MDPI journals
Dr. Ricardo Ruiz-Villaverde

E-Mail Website
Guest Editor
Dermatology Department, Hospital Universitario San Cecilio, Instituto Biosanitario de Granada, Ibs, 18016 Granada, Spain
Interests: psoriasis; atopic dermatitis; biological treatments
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue entitled “State-of-the-Art Dermatology in Spain” aims to highlight the latest advances, challenges, and innovations in dermatological research and clinical practice in Spain. This Special Issue will feature original research and comprehensive reviews on emerging therapies, diagnostic techniques, and the evolving landscape of dermatological diseases, with a particular focus on translational medicine and personalized treatment approaches.

Dr. Francisco José Navarro-Triviño
Dr. Ricardo Ruiz-Villaverde
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dermatological research
  • dermatology
  • skin disease
  • psoriasis
  • atopic dermatitis
  • urticaria
  • alopecia areata

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Published Papers (2 papers)

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Research

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13 pages, 835 KB  
Article
Epidemiology of Dermatomyositis and Other Idiopathic Inflammatory Myopathies in Northern Spain
by Cristina Corrales-Selaya, Diana Prieto-Peña, David Martínez-López, Fabricio Benavides-Villanueva and Ricardo Blanco
Biomedicines 2025, 13(10), 2537; https://doi.org/10.3390/biomedicines13102537 - 17 Oct 2025
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Abstract
Background/Objectives: The epidemiology of dermatomyositis (DM) and other idiopathic inflammatory myopathies (IIMs) remains not well established, especially in the Mediterranean region. We aimed to estimate the prevalence and incidence of IIM in a well-defined population of South Europe using standardized classification criteria. [...] Read more.
Background/Objectives: The epidemiology of dermatomyositis (DM) and other idiopathic inflammatory myopathies (IIMs) remains not well established, especially in the Mediterranean region. We aimed to estimate the prevalence and incidence of IIM in a well-defined population of South Europe using standardized classification criteria. Methods: This population-based study included all IIM patients diagnosed from January 2000 to December 2022 in Cantabria, Northern Spain. IIM diagnosis was confirmed by fulfillment of the 2017 EULAR/ACR classification criteria or, alternatively, by European Neuro Muscular Center criteria for immune-mediated necrotizing myopathy (IMNM) and Connors’ criteria for antisynthetase syndrome (ASyS). Prevalence and incidence were expressed in cases per 100,000. A literature review was also performed. Results: A total of 60 patients (41 women, 19 men; mean age 52.6 ± 18.8 years) were included. The prevalence of IIM was 20 cases per 100,000 population [95% CI 14.5–25.1], and the annual incidence rate was 0.9 cases per 100,000 person-years [95% CI 0.6–1.14]. A significant upward trend in IIM incidence was observed with an estimated annual percentage change of 5.74% (95% CI: 2.16%–9.44%, p = 0.0015). The most common subtype was DM (n = 31, 51.7%), followed by ASyS (n = 17, 24%), IMNM (n = 9, 14.6%), and polymyositis (PM) (n = 3, 4.7%). No inclusion body myositis (IBM) cases were identified. Conclusions: Incidence and prevalence of IIM align with prior reports. We observed an increase in IIM incidence and a shift in subtype distribution, with ASyS and IMNM becoming more frequent. These findings have clinical relevance, as each IIM subtype carries distinct prognostic and therapeutic implications. Full article
(This article belongs to the Special Issue State-of-the-Art Dermatology in Spain)
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Review

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17 pages, 1299 KB  
Review
Seborrheic Dermatitis Revisited: Pathophysiology, Diagnosis, and Emerging Therapies—A Narrative Review
by Francisco José Navarro Triviño, Juan Pablo Velasco Amador and Irene Rivera Ruiz
Biomedicines 2025, 13(10), 2458; https://doi.org/10.3390/biomedicines13102458 - 9 Oct 2025
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Abstract
Background: Seborrheic dermatitis (SD) is a chronic, recurrent inflammatory dermatosis that primarily affects seborrheic areas such as the scalp, face, and upper trunk. Its etiology is multifactorial, involving sebaceous gland activity, immune dysregulation, skin barrier dysfunction, and alterations in the microbiome, particularly [...] Read more.
Background: Seborrheic dermatitis (SD) is a chronic, recurrent inflammatory dermatosis that primarily affects seborrheic areas such as the scalp, face, and upper trunk. Its etiology is multifactorial, involving sebaceous gland activity, immune dysregulation, skin barrier dysfunction, and alterations in the microbiome, particularly an overgrowth of Malassezia spp. Objective: This review provides an updated overview of the pathophysiological mechanisms of seborrheic dermatitis and critically examines current therapies and emerging treatments. Methods: A narrative review of the recent literature was conducted, including preclinical studies, clinical trials, and real-world evidence regarding SD pathogenesis and therapy. Special attention was paid to molecular pathways, microbiome-modulating strategies, and novel therapeutic agents. Results: Advances in transcriptomic and microbiome profiling have revealed a complex immunoinflammatory environment in SD, involving predominantly Th1, Th17, and Th22 axes. Conventional therapies are mainly based on antifungals, topical corticosteroids, and calcineurin inhibitors. However, new therapeutic approaches are under investigation, including PDE4 inhibitors (roflumilast, crisaborole, and apremilast), topical and oral JAK inhibitors, probiotics, and microbiome-targeted therapies. These agents offer promising results in selected patients, particularly those with refractory disease or facial involvement. Conclusions: SD remains a challenging condition due to its relapsing course and limited long-term therapeutic options. Emerging therapies represent a valuable opportunity to address unmet clinical needs, particularly in patients with severe, recurrent, or treatment-resistant forms. Full article
(This article belongs to the Special Issue State-of-the-Art Dermatology in Spain)
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