Viruses in Cancer and Therapy
A special issue of Biomedicines (ISSN 2227-9059).
Deadline for manuscript submissions: closed (15 August 2018) | Viewed by 21840
Special Issue Editor
Interests: herpesvirology; latency and viral reactivation; genetic and epigenetic factors of viral replication; zika virus pathogenesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The close relationship between viruses and tumors has a long history, dating back to 1930s, when the first evidence of tumor-causing viruses was presented. Since then, many oncoviruses have been discovered, including the Epstein-Barr virus, human papilloma virus, Hepatitis C virus, etc. Oncoviruses differ in their tropism and mechanisms of cancerogenesis, which makes them one of the most versatile group of pathogens. Despite the significant advances in our understanding of the mechanisms of transmission, tumor development and metastasis, many aspects of cancer pathogenesis remain unknown.
Traditionally, the role of viruses in tumor growth was limited to cancerogenesis, where viruses were expected to interrupt cell growth control to establish malignancy. However, this paradigm is changing with the introduction of oncolytic viruses. Oncolytic viruses are defined as viruses (genetically-engineered or naturally-occurring) capable of selectively killing cancer cells, leaving the normal tissues unharmed. This is a novel approach for the treatment of cancer that has many advances compared to conventional combinations of chemotherapy and radiation.
We invite authors to contribute original manuscripts, case reports, clinical trials, as well as reviews focused on viruses in cancer and therapy.
Potential topics include, but are not limited to:
- Recent discoveries on cancers caused by viruses (genetic, proteomic, etc.)
- In vitro and in vivo studies aimed to identify mechanisms of virus-causing tumors;
- Biomarkers for diagnosis and therapy of virus caused cancers;
- Transcriptome and proteome analysis of various tumors caused by viruses and oncolytic viruses;
- Bioinformatics approaches to characterize oncoviruses and oncolytic viruses related to clinical presentation, treatment efficacy and prognosis of various cancers;
- Novel therapeutic approaches for treatment of cancers using viruses;
- Mechanisms of the immune system, evasion and development of resistance to chemo and radio therapy by oncoviruses
Assoc. Prof. Subhash C. Verma
Guest Editor
Manuscript Submission Information
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Keywords
- cancer
- oncovirus
- oncolytic virus
- immunity
- immune response
- therapy
- cancer stem cells
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