Applications of Microbiome Research and Multi-Omics Integration in Diseases and Therapeutics

Dear Colleagues,

Microbiome research and multi-omics integration have revolutionized our understanding of the complex interactions between the microbiome and health and have emerged as powerful tools in potential therapeutics. By interrogating complex interactions between the microbiome and the host, researchers can shed light on the mechanisms of various diseases such as inflammatory diseases, metabolic disease, cancers, and neurological disorders. The identification of disease-associated microbiota signatures and host biomarkers could serve early disease detection and identify potential therapeutic targets for personalized medicine.

Integrating multi-omics data, including genomics, transcriptomics, proteomics, and metabolomics, with microbiome data has allowed for the occurrence of a more comprehensive understanding of disease pathways and the influence of gut microbes on various health conditions.

In conclusion, the synergy between microbiome research and multi-omics integration holds immense promise for uncovering disease mechanisms, identifying biomarkers, advancing precision medicine, and developing innovative therapeutics. However, more research is needed to fully utilize the potential of these technologies. Hence, we invite researchers from various disciplines to contribute original research articles, review papers, and case studies to this Special Issue. Potential topics of interest include, but are not limited to:

1. The role of the gut microbiome in various diseases and disorders;
2. Multi-omics integration for disease biomarker discovery;
3. Microbiome-based therapeutic approaches, including fecal microbiota transplantation (FMT) and probiotics;
4. Precision medicine applications leveraging microbiome and multi-omics data;
5. Microbiome–host interactions and their implications in disease pathogenesis;
6. Applications of microbiome research in cancer, autoimmune diseases, metabolic disorders, and neurological conditions.

Dr. Guanglin Zhang
Guest Editor

Manuscript Submission Information

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• gut microbiome
• multi-omics
• metabolic disorders
• inflammatory diseases
• probiotics
• neurological disorders
• cancer
• dietary interventions
• biomarker discovery
• microbiota transplantation