Pathogenesis, Disease Detection and Novel Therapeutic Approaches for Osteosarcoma

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 619

Special Issue Editor


E-Mail Website
Guest Editor
Department of Small Animal Clinical Sciences, Virginia Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA
Interests: histotripsy-focused ultrasound; high-frequency irreversible electroporation; immunotherapy; primary and metastatic osteosarcoma; tumor ablation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, “Pathogenesis, Disease Detection and Novel Therapeutic Approaches for Osteosarcoma”, will highlight recent advances in the understanding of the factors and pathways that contribute to the pathogenesis of osteosarcoma and emerging methods to diagnose and treat osteosarcoma.

Osteosarcoma is a devastating cancer that has not seen major improvements in disease outcomes in decades. A deeper understanding of the pathogenesis of osteosarcoma can pave the way to developing disease prevention strategies. The advent of exciting diagnostic tools, such as liquid biopsy, to enable early disease detection and the subsequent early treatment of disease can lead to improved disease outcomes. Emerging innovative therapeutic approaches to treat primary and metastatic osteosarcoma are greatly needed to improve patient’s quality of life and survival expectations.

We cordially invite authors in the field to submit original research or review articles pertaining to these essential and rapidly progressing topics.

Dr. Joanne Tuohy
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteosarcoma
  • cancer pathogenesis
  • early disease detection
  • immunotherapy
  • targeted therapy
  • combinatorial therapy
  • non-surgical therapy
  • radiation
  • tumor ablation
  • personalized patient-specific therapy

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Other

26 pages, 3851 KiB  
Systematic Review
Sulforaphane’s Role in Osteosarcoma Treatment: A Systematic Review and Meta-Analysis of Preclinical Studies
by Polymnia Louka, Nuno Ferreira and Antonia Sophocleous
Biomedicines 2025, 13(5), 1048; https://doi.org/10.3390/biomedicines13051048 - 25 Apr 2025
Viewed by 225
Abstract
Background/Objectives: Osteosarcoma (OSA) is the most common bone cancer, characterized by rapid progression and poor prognosis. The isothiocyanate sulforaphane (SFN), has gained scientific interest because of its potent anticancer properties. The aim of this study was to conduct a systematic review of [...] Read more.
Background/Objectives: Osteosarcoma (OSA) is the most common bone cancer, characterized by rapid progression and poor prognosis. The isothiocyanate sulforaphane (SFN), has gained scientific interest because of its potent anticancer properties. The aim of this study was to conduct a systematic review of research examining the effectiveness of SFN as a treatment for OSA. Methods: A literature search was conducted using MEDLINE, EMBASE, and Web of Science. Studies evaluating the therapeutic efficacy of SFN on OSA were included, while studies examining the effects of isothiocyanates other than SFN were excluded. The quality of the studies was evaluated using the OHAT risk of bias rating tool, and the meta-analysis was conducted using RevMan. Cancer-related outcomes evaluated included cell viability/migration/invasion, cell cycle arrest, apoptosis induction, antioxidant activity, colony formation, and tumour size. A protocol describing the review plan was registered to INPLASY (INPLASY202530001). Results: Ten articles were considered eligible for qualitative synthesis and meta-analysis. All articles included in vitro studies, with two also incorporating in vivo studies, utilizing a combination of human, canine, and murine OSA cell lines. This review indicates that SFN could be beneficial in the treatment of OSA, particularly by reducing cell viability, inducing apoptosis, arresting the cell cycle, and decreasing invasiveness and migration. It emphasizes dose-dependent effects, the need for human trials, and highlights limitations like study heterogeneity and SFN’s bioavailability challenges. Conclusions: This review explores SFN’s potential in OSA at the preclinical stage, focusing on cell apoptosis and proliferation. It highlights promising evidence but calls for more human trials. This research received no external funding. Full article
Show Figures

Figure 1

Back to TopTop