Obesity and Diabetes: Impact on Cancer
Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 6465
Obesity, diabetes, and cancer are closely linked diseases whose prevalence is increasing rapidly worldwide. A significant body of evidence indicates that metabolic disturbances are associated with cancer incidence, morbidity, and mortality. Obesity influences treatment selection (including chemotherapy dosage) and affects chemotherapy toxicity and surgical complications. However, the biological and molecular mechanisms of this association are yet to be fully identified. Since obesity/diabetes and cancer are heterogeneous disorders with complex and changing pathogenic and clinical features, there are certainly multiple pathways linking these diseases. In particular, metabolic alterations may facilitate carcinogenesis and/or aggressive neoplastic behaviour by i) general-systemic mechanisms that affect all tissues and ii) site specific-local mechanisms affecting the carcinogenesis of a particular organ, with an important involvement in tumour stroma. This Special Issue will focus on understanding the molecular mechanisms (systemic and/or local) that drive metabolic imbalance progressing to cancer development. We are also interested in the discovery of new targets and markers at either the clinical or preclinical level.
Dr. Vittoria D’Esposito
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- metabolic alterations and cancer progression (in vitro, in vivo, and clinical studies)
- metabolic imbalance and drug resistance in cancer
- epigenetic mechanisms linking obesity/diabetes and cancer
- impact of “obesogenic” factors (chemical pollutants, diet) on cancer
- targeting tumour–stroma interaction in dysmetabolic conditions
- soluble factors (cytokines, chemokines and growth factors) and exosomes in metabolic diseases and cancer