Biomedicines

Journal Browser

► Journal Browser

State-of-the-Art Nanomedicine and Nanobiotechnology in Europe

Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Nanomedicine and Nanobiology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 4083

Share This Special Issue

Special Issue Information

Dear Colleagues,

Several advances in nanotechnology have been achieved in the past few years, overcoming major challenges underpinning the biotechnological and medical fields. Together with the development of novel materials, these fields have witnessed a paradigm shift in the strategies for various applications ranging from drug delivery and tissue engineering to biosensors and microfluidics. In addition, multifunctional smart nanomaterials are increasingly becoming a dominant means to achieve complex tasks in nanomedicine and nanobiotechnology.

This Special Issue aims to attract the academic and scientific communities within the nanomaterials field to contribute with developments on nanomedicine and nanobiotechnological applications. We hope this Special Issue will provide a collection of original articles and reviews addressing the current state-of-the-art in addition to innovative and cutting-edge research related to the principles, fabrication, safety and application of nanomaterials as well as the translation to clinical trials. The systems can include (but are not limited to) biomaterials, carbonaceous materials, metal-organic frameworks, magnetic and/or plasmonic materials.

We look forward to receiving your contributions

Dr. Elisabete M. S. Castanheira
Dr. Sérgio R. S. Veloso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

nanomaterials
nanomedicine
nanobiotechnology
multifunctional materials
smart materials

Published Papers (2 papers)

Download All Papers

Research

Jump to: Review

16 pages, 3450 KiB

Open AccessArticle

Magnetoliposomes Containing Multicore Nanoparticles and a New Antitumor Thienopyridine Compound with Potential Application in Chemo/Thermotherapy

by Fábio A. C. Lopes, André V. F. Fernandes, Juliana M. Rodrigues, Maria-João R. P. Queiroz, Bernardo G. Almeida, Ana Pires, André M. Pereira, João P. Araújo, Elisabete M. S. Castanheira, Ana Rita O. Rodrigues and Paulo J. G. Coutinho

Biomedicines 2022, 10(7), 1547; https://doi.org/10.3390/biomedicines10071547 - 29 Jun 2022

Cited by 8 | Viewed by 2202

Abstract

Multicore magnetic nanoparticles of manganese ferrite were prepared using carboxymethyl dextran as an agglutinating compound or by an innovative method using melamine as a cross-coupling agent. The nanoparticles prepared using melamine exhibited a flower-shape structure, a saturation magnetization of 6.16 emu/g and good capabilities for magnetic hyperthermia, with a specific absorption rate (SAR) of 0.14 W/g. Magnetoliposome-like structures containing the multicore nanoparticles were prepared, and their bilayer structure was confirmed by FRET (Förster Resonance Energy Transfer) assays. The nanosystems exhibited sizes in the range of 250–400 nm and a low polydispersity index. A new antitumor thienopyridine derivative, 7-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]thieno[3,2-b]pyridine, active against HeLa (cervical carcinoma), MCF-7 (breast adenocarcinoma), NCI-H460 (non-small-cell lung carcinoma) and HepG2 (hepatocellular carcinoma) cell lines, was loaded in these nanocarriers, obtaining a high encapsulation efficiency of 98 ± 2.6%. The results indicate that the new magnetoliposomes can be suitable for dual cancer therapy (combined magnetic hyperthermia and chemotherapy). Full article

(This article belongs to the Special Issue State-of-the-Art Nanomedicine and Nanobiotechnology in Europe)

► Show Figures

Figure 1

Review

Jump to: Research

15 pages, 935 KiB

Open AccessReview

Nanotechnology Innovations in Pediatric Cardiology and Cardiovascular Medicine: A Comprehensive Review

by Stefana Maria Moisa, Alexandru Burlacu, Lacramioara Ionela Butnariu, Corina Maria Vasile, Crischentian Brinza, Elena Lia Spoiala, Alexandra Maștaleru, Maria Magdalena Leon, Solange Tamara Rosu, Radu Vatasescu and Eliza Elena Cinteză

Biomedicines 2024, 12(1), 185; https://doi.org/10.3390/biomedicines12010185 - 15 Jan 2024

Viewed by 1294

Abstract

(1) Background: Nanomedicine, incorporating various nanoparticles and nanomaterials, offers significant potential in medical practice. Its clinical adoption, however, faces challenges like safety concerns, regulatory hurdles, and biocompatibility issues. Despite these, recent advancements have led to the approval of many nanotechnology-based products, including those for pediatric use. (2) Methods: Our approach included reviewing clinical, preclinical, and animal studies, as well as literature reviews from the past two decades and ongoing trials. (3) Results: Nanotechnology has introduced innovative solutions in cardiovascular care, particularly in managing myocardial ischemia. Key developments include drug-eluting stents, nitric oxide-releasing coatings, and the use of magnetic nanoparticles in cardiomyocyte transplantation. These advancements are pivotal for early detection and treatment. In cardiovascular imaging, nanotechnology enables noninvasive assessments. In pediatric cardiology, it holds promise in assisting the development of biological conduits, synthetic valves, and bioartificial grafts for congenital heart defects, and offers new treatments for conditions like dilated cardiomyopathy and pulmonary hypertension. (4) Conclusions: Nanomedicine presents groundbreaking solutions for cardiovascular diseases in both adults and children. It has the potential to transform cardiac care, from enhancing myocardial ischemia treatment and imaging techniques to addressing congenital heart issues. Further research and guideline development are crucial for optimizing its clinical application and revolutionizing patient care. Full article

(This article belongs to the Special Issue State-of-the-Art Nanomedicine and Nanobiotechnology in Europe)

► Show Figures