Endocrine Cancers: Pathophysiology and Therapy

Dear Colleagues,

There has been significant progress made in the understanding of cancers affecting the endocrine glands, namely the thyroid, parathyroid, adrenal, and neuroendocrine glands, as a result of genome, epigenome, and transcriptome analyses. This knowledge has paved the way for precision and personalized treatments for patients with endocrine cancers of both sporadic and inheritable origins. In the field of thyroidology, preoperative molecular markers have enabled preoperative detection of cancer in nodules considered indeterminate with fair accuracy, thereby avoiding unnecessary surgery. Molecular and pathway analysis has allowed for better prognostic classification and response prediction for targeted therapies, especially for multikinase inhibitors. Genetic dissection of adrenal cancers and paragangliomas has revealed the roles played by IGF and WNT signalling pathways in the pathogenesis of these aggressive tumours, but not much progress has been made in the treatment of advanced disease, especially when metastasis develops.

In this Special Issue, we aim to focus on the molecular pathways and targeted therapies that include basic science, preclinical, and translational studies in the management of endocrine cancers.

Dr. Rajeev Parameswaran
Dr. Amit Agrawal
Guest Editors

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