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Biomedicines
Special Issues
Soft Electronics Enabled Tissue Engineering and Characterization
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Soft Electronics Enabled Tissue Engineering and Characterization

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 6739

Special Issue Editor

Dr. Muyang Lin

E-Mail Website
Guest Editor
Department of Nanoengineering, University of California San Diego, La Jolla, CA 92093, USA
Interests: soft electronics; tissue characterization; ultrasound imaging; healthcare
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Emerging soft electronics are paving the way for advancements in tissue engineering and characterization. Their tissue-mimicking properties present unparalleled opportunities for forming flexible tissue interfaces, which is crucial for various medical applications. However, transitioning these innovations into clinical settings—where high tissue penetration, efficacy, and accuracy are paramount—poses significant challenges. Thus, there is an urgent need for advanced technologies to effectively engineer and characterize tissues.

This Special Issue aims to highlight the latest research in tissue engineering and characterization, with a particular focus on soft electronics. We are seeking studies that not only push the boundaries of what is currently possible but also address, among others, the following challenges: the regulation of biomaterials in tissue repair, drug delivery, wearable sensors for deep tissue sensing, and tissue characterization techniques to facilitate clinical diagnostics.

We kindly invite you to submit a manuscript to this Special Issue. Full papers, communications, and reviews that expand the frontiers of using soft electronics in healthcare are all welcome.

Dr. Muyang Lin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • soft electronics
  • tissue engineering
  • drug delivery
  • tissue repair
  • tissue characterization
  • healthcare

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Published Papers (2 papers)

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Research

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19 pages, 12524 KiB  
Article
Ultrasound-Compatible Electrode for Functional Electrical Stimulation
by Sunho Moon, Xiangming Xue, Vidisha Ganesh, Darpan Shukla, Benjamin C. Kreager, Qianqian Cai, Huaiyu Wu, Yong Zhu, Nitin Sharma and Xiaoning Jiang
Biomedicines 2024, 12(8), 1741; https://doi.org/10.3390/biomedicines12081741 - 2 Aug 2024
Cited by 3 | Viewed by 1843
Abstract
Functional electrical stimulation (FES) is a vital method in neurorehabilitation used to reanimate paralyzed muscles, enhance the size and strength of atrophied muscles, and reduce spasticity. FES often leads to increased muscle fatigue, necessitating careful monitoring of the patient’s response. Ultrasound (US) imaging [...] Read more.
Functional electrical stimulation (FES) is a vital method in neurorehabilitation used to reanimate paralyzed muscles, enhance the size and strength of atrophied muscles, and reduce spasticity. FES often leads to increased muscle fatigue, necessitating careful monitoring of the patient’s response. Ultrasound (US) imaging has been utilized to provide valuable insights into FES-induced fatigue by assessing changes in muscle thickness, stiffness, and strain. Current commercial FES electrodes lack sufficient US transparency, hindering the observation of muscle activity beneath the skin where the electrodes are placed. US-compatible electrodes are essential for accurate imaging and optimal FES performance, especially given the spatial constraints of conventional US probes and the need to monitor muscle areas directly beneath the electrodes. This study introduces specially designed body-conforming US-compatible FES (US-FES) electrodes constructed with a silver nanowire/polydimethylsiloxane (AgNW/PDMS) composite. We compared the performance of our body-conforming US-FES electrode with a commercial hydrogel electrode. The findings revealed that our US-FES electrode exhibited comparable conductivity and performance to the commercial one. Furthermore, US compatibility was investigated through phantom and in vivo tests, showing significant compatibility even during FES, unlike the commercial electrode. The results indicated that US-FES electrodes hold significant promise for the real-time monitoring of muscle activity during FES in clinical rehabilitative applications. Full article
(This article belongs to the Special Issue Soft Electronics Enabled Tissue Engineering and Characterization)
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Review

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37 pages, 10678 KiB  
Review
E-Skin and Its Advanced Applications in Ubiquitous Health Monitoring
by Xidi Sun, Xin Guo, Jiansong Gao, Jing Wu, Fengchang Huang, Jia-Han Zhang, Fuhua Huang, Xiao Lu, Yi Shi and Lijia Pan
Biomedicines 2024, 12(10), 2307; https://doi.org/10.3390/biomedicines12102307 - 11 Oct 2024
Cited by 8 | Viewed by 4132
Abstract
E-skin is a bionic device with flexible and intelligent sensing ability that can mimic the touch, temperature, pressure, and other sensing functions of human skin. Because of its flexibility, breathability, biocompatibility, and other characteristics, it is widely used in health management, personalized medicine, [...] Read more.
E-skin is a bionic device with flexible and intelligent sensing ability that can mimic the touch, temperature, pressure, and other sensing functions of human skin. Because of its flexibility, breathability, biocompatibility, and other characteristics, it is widely used in health management, personalized medicine, disease prevention, and other pan-health fields. With the proposal of new sensing principles, the development of advanced functional materials, the development of microfabrication technology, and the integration of artificial intelligence and algorithms, e-skin has developed rapidly. This paper focuses on the characteristics, fundamentals, new principles, key technologies, and their specific applications in health management, exercise monitoring, emotion and heart monitoring, etc. that advanced e-skin needs to have in the healthcare field. In addition, its significance in infant and child care, elderly care, and assistive devices for the disabled is analyzed. Finally, the current challenges and future directions of the field are discussed. It is expected that this review will generate great interest and inspiration for the development and improvement of novel e-skins and advanced health monitoring systems. Full article
(This article belongs to the Special Issue Soft Electronics Enabled Tissue Engineering and Characterization)
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