Neurodevelopmental and Neuropsychiatric Disorders in Animal Models

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 615

Special Issue Editor


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Guest Editor
Laboratório de Neurofisiologia, Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro 20550-170, RJ, Brazil
Interests: nicotine addiction; schizophrenia; comorbidity; animal models of disease; brain development

Special Issue Information

Dear Colleagues,

Neurodevelopmental and neuropsychiatric disorders are complex conditions that can have a myriad of clinical manifestations and are influenced by multiple biological, environmental and genetic factors. Considering that access to human data may be hampered by ethical concerns, technical and analytical limitations, the use of animal models stands out as an alternative of translational significance.

This Special Issue intends to gather information aiming to help fill knowledge gaps and provide valuable insights into the complex nature of neurodevelopmental and neuropsychiatric disorders. Accordingly, the scope of the issue covers a broad range of topics from the understanding of their molecular bases to the development of new therapeutic strategies.

Preclinical research articles, reviews, and perspectives that cover these and related topics are welcome.

Prof. Dr. Yael Abreu-Villaça
Guest Editor

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Keywords

  • mood disorder
  • mental disorder
  • substance use disorder
  • autism spectrum disorder (ASD)
  • attention-deficit/hyperactive disorder (ADHD)
  • depression and anxiety disorders
  • schizophrenia
  • bipolar disorder
  • epilepsy
  • eating disorders

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Published Papers (1 paper)

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Research

28 pages, 3151 KiB  
Article
Nucleus Accumbens Proteome Disbalance in an Adolescent Mouse Model of Schizophrenia and Nicotine Misuse Comorbidity
by Thainá Pereira Souza, Andrés Rodríguez-Vega, Ana Carolina Dutra-Tavares, Keila A. Semeão, Claudio Carneiro Filgueiras, Anderson Ribeiro-Carvalho, Alex Christian Manhães and Yael Abreu-Villaça
Biomedicines 2025, 13(4), 901; https://doi.org/10.3390/biomedicines13040901 - 8 Apr 2025
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Abstract
Background/Objectives: Schizophrenia and nicotine misuse are a comorbid condition that frequently develops during adolescence. Considering the role of the nucleus accumbens (NAcc) as a common neurobiological substrate for these psychiatric disorders, label-free proteomics was employed to identify NAcc deregulated proteins in male [...] Read more.
Background/Objectives: Schizophrenia and nicotine misuse are a comorbid condition that frequently develops during adolescence. Considering the role of the nucleus accumbens (NAcc) as a common neurobiological substrate for these psychiatric disorders, label-free proteomics was employed to identify NAcc deregulated proteins in male and female mouse models of schizophrenia with a history of adolescent nicotine exposure. Methods: Phencyclidine was used to model schizophrenia, and minipump infusions were used to model nicotine misuse. Results: Enrichment Reactome pathway and protein–protein interaction analyses showed that the cytoskeleton and associated synaptic plasticity mechanisms, energy metabolism, and nervous system development were affected in both sexes. In particular, Ncam1 (Neural cell adhesion molecule 1) could be of interest as a candidate marker of synaptic plasticity disbalance. Its deregulation in the NAcc of both sexes suggests that it lies at the core of the comorbidity pathophysiology. When considering sex-selective effects, Cs (Citrate synthase) and Mapk3 (Mitogen-activated protein kinase 3) were identified as exclusively deregulated in female and male mice, respectively. Since both proteins were previously shown to be exclusively deregulated in the medial prefrontal cortex of co-modeled mice, a common mesocortical and mesolimbic system effect can be inferred, supporting the role of aberrant energy metabolism and synaptic plasticity in the comorbidity model. Conclusions: The current data provide insights into the NAcc proteome disbalance in an adolescent preclinical model of combined schizophrenia and nicotine misuse, pointing to relevant pathways and early markers of the comorbidity. Full article
(This article belongs to the Special Issue Neurodevelopmental and Neuropsychiatric Disorders in Animal Models)
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