Genetic Research on Colorectal Cancers
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 23
Special Issue Editor
2. Cancer Center, Zhejiang University, Hangzhou, China
Interests: colorectal cancer molecular subtyping; microsatellite instability; epigenetic age; single cell data exploration
Special Issue Information
Dear Colleagues,
Colorectal cancer (CRC) is a highly heterogeneous disease caused by the sequential accumulation of driver gene mutations. Recent advances in large cohort genomic investigations have rapidly improved our understanding of the occurrence, early onset, drug resistance, and metastasis of CRC. Additionally, causal inference by mendelian randomization bridges the gap in research on genetic diversity and exposure. Meanwhile, in targeted therapy, CRC resistance to chemoradiotherapy or immunotherapy caused by a specific genetic mutation, such as KRAS or BRAF, has the potential to extend patients’ survival. The early detection of CRC by ctDNA has also been shown to achieve early diagnosis and treatment. To this end, this Special Issue of Biomedicines invites clinicians and scientists to submit reviews, research, and letters presenting experimental, clinical, and bioinformatic big data sequencing results.
Dr. Wangxiong Hu
Guest Editor
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Keywords
- high microsatellite instability
- epigenetic age acceleration
- spatial omics and single-cell sequencing
- cold tumors and immunotherapy
- driver gene
- DNA replication repair
- liquid biopsy
- ctDNA
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