Pyroptosis and Cellular Stress: Emerging Mechanisms and Therapeutic Targets
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 28
Special Issue Editor
2. Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA
Interests: pyroptosis; inflammation; inflammasome; cancer immunotherapy; gasdermin; mitochondria; ROS
Special Issue Information
Dear Colleagues,
This Special Issue, "Pyroptosis and Cellular Stress: Emerging Mechanisms and Therapeutic Targets", will focus on the molecular mechanisms underlying pyroptosis and its intricate relationship with various forms of cellular stress, as well as the therapeutic potential of modulating these pathways in inflammation, cancer, and immune-related diseases.
Pyroptosis is a pro-inflammatory form of programmed cell death driven by gasdermin-mediated membrane pore formation and the release of cytokines such as IL-1β and IL-18. Initially identified as a host defense response to infection, pyroptosis is now recognized as a pivotal mechanism in sterile inflammation, tumor immunity, metabolic disorders, and aging-related conditions. Various cellular stressors—including mitochondrial dysfunction, oxidative stress, endoplasmic reticulum (ER) stress, and DNA damage—may initiate or potentiate pyroptotic signaling through inflammasome activation or direct modulation of gasdermin proteins.
Unraveling the molecular crosstalk between cellular stress pathways and pyroptosis is essential for the development of precision therapeutics aimed at modulating inflammatory responses and cell death.
We invite authors to submit original research (basic, translational, or clinical) and review articles on the molecular regulation, pathophysiological roles, and therapeutic targeting of pyroptosis and cellular stress pathways. Potential topics include, but are not limited to:
- Crosstalk between pyroptosis and cellular stress signaling (ROS, mitochondrial stress, ER stress, etc.);
- The role of pyroptosis in cancer immunity, infection, inflammatory disease, or aging;
- Multi-omics and structural studies illuminating pyroptotic mechanisms;
- Impact of cellular metabolism and immunometabolism on inflammasome activation and pyroptotic responses;
- Inflammasome-independent pathways of inflammatory cell death and their pathological relevance
Dr. Gang Du
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pyroptosis
- cellular stress
- ROS
- programmed cell death
- gasdermin
- cytokines
- inflammation
- infection
- cellular metabolism
- immunometabolism
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