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Biomedicines
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Development of Bone Anabolic Agents and Scaffolds for Improved Fracture...
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Development of Bone Anabolic Agents and Scaffolds for Improved Fracture Healing

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1165

Special Issue Editor

Dr. Subhashis Pal

E-Mail Website
Guest Editor
Division of Endocrinology, Metabolism, and Lipids, Emory University School of Medicine, Atlanta, GA 30322, USA
Interests: osteoimmunology; bone biology; fracture healing; immuno-oncology

Special Issue Information

Dear Colleagues, 

This Special Issue will mainly focus on new bone anabolic agent development and the use of different tissue scaffolds for improved fracture healing. 

Fracture healing is a complex biological process, triggered by trauma injury or in association with osteoporosis. Depending on its severity, location and patient bone quality, delayed, impaired or nonunion fracture healing can occur. Addressing these situations is extremely critical as they lead to reduced mobility, excessive pain, bone infections and bone deformities. Therefore, the development of bone anabolic agents and tissue scaffolds to improve fracture healing is an unmet medical need. In this issue, we are looking for research articles using novel bone anabolic agents and tissue scaffolds for fracture healing in relevant animal models. Human case studies related to novel approaches for nonunion fracture healing are also a topic of interest for this Special Issue. Current research indicates that probiotics and gut microbiomes could play a beneficial role in fracture healing. To move forward in this direction, articles focusing on the use of probiotics or the gut–fracture healing axis will be given special emphasis for this issue. 

Dr. Subhashis Pal
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone anabolic agents
  • fracture healing
  • nonunion fracture
  • osteoblast
  • gut–bone axis for fracture healing
  • probiotics
  • osteoporotic fracture
  • tissue scaffold for fracture healing

Published Papers (1 paper)

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Research

12 pages, 2486 KiB  
Article
Targeted Delivery of Abaloparatide to Spinal Fusion Site Accelerates Fusion Process in Rats
by Jeffery J. Nielsen, Stewart A. Low, Christopher Chen, Xinlan Li, Ephraim Mbachu, Lina Trigg, Siyuan Sun, Madeline Tremby, Rahul Hadap and Philip S. Low
Biomedicines 2024, 12(3), 612; https://doi.org/10.3390/biomedicines12030612 - 8 Mar 2024
Viewed by 817
Abstract
Spinal fusions are performed to treat congenital skeletal malformations, spondylosis, degenerative disk diseases, and other pathologies of the vertebrae that can be resolved by reducing motion between neighboring vertebrae. Unfortunately, up to 100,000 fusion procedures fail per year in the United States, suggesting [...] Read more.
Spinal fusions are performed to treat congenital skeletal malformations, spondylosis, degenerative disk diseases, and other pathologies of the vertebrae that can be resolved by reducing motion between neighboring vertebrae. Unfortunately, up to 100,000 fusion procedures fail per year in the United States, suggesting that efforts to develop new approaches to improve spinal fusions are justified. We have explored whether the use of an osteotropic oligopeptide to target an attached bone anabolic agent to the fusion site might be exploited to both accelerate the mineralization process and improve the overall success rate of spinal fusions. The data presented below demonstrate that subcutaneous administration of a modified abaloparatide conjugated to 20 mer of D-glutamic acid not only localizes at the spinal fusion site but also outperforms the standard of care (topically applied BMP2) in both speed of mineralization (p < 0.05) and overall fusion success rate (p < 0.05) in a posterior lateral spinal fusion model in male and female rats, with no accompanying ectopic mineralization. Because the bone-localizing conjugate can be administered ad libitum post-surgery, and since the procedure appears to improve on standard of care, we conclude that administration of a bone-homing anabolic agent for improvement of spinal fusion surgeries warrants further exploration. Full article
(This article belongs to the Special Issue Development of Bone Anabolic Agents and Scaffolds for Improved Fracture Healing)
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