Regulation of the Hypoxic Response by Noncoding RNA
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular Genetics and Genetic Diseases".
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 304
Special Issue Editor
Interests: HIF-1; HIF-2; HIF-3; unfolded protein response; IRE1; XBP1
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The imbalance between oxygen availability and demand at both tissue and cellular levels, termed “hypoxia”, activates the fast global reprogramming of gene expression in order to secure survival and to restore oxygen homeostasis. Furthermore, since the oxygen supply can be rapidly restored, the hypoxia response is also responsible for minimizing the risk of oxidative damage, as well as the timely activation of cell death in case the oxygen levels cannot be restored. Hence, the aptness to acquire the therapeutic regime upon the molecular mechanism underlying hypoxic response persists in the interest of modern therapeutic approaches for ischemic events, stroke, or myocardial infarction, as well as the majority of human tumors, macular degeneration, glaucoma progression, and diabetic retinopathy. However, although the Hypoxia Inducible Factors (HIFs) have been recognized as master regulators of hypoxic response, specific disease-oriented therapeutic modulation of their activity remains very challenging. Notably, recent studies defined novel noncoding RNA-based mechanisms that provide a hypoxic response with novel regulatory circuits and thus therapeutic opportunities. MicroRNAs, long noncoding RNAs, PiRNA, and other RNA molecules can efficiently shape the course and effects of HIF activity and consequently decide the fate of hypoxic cells. Furthermore, the development of synthetic analogues of these molecules and dedicated delivery approaches opens new therapeutic opportunities that could change patients’ lives.
Taken together, this Special Issue focuses on both the biological and therapeutic role of noncoding RNA in governing cell signaling and fate under hypoxia or ischemia.
Dr. Rafał Bartoszewski
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- miRNA
- lncRNAs
- morpholinos
- siRNA
- HIF
- piRNA
- hypoxia
- ischemia
- cancer
- cardiovascular diseases
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
