Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.8
4.5
Journals
Biomedicines
Special Issues
Biomedical Devices—Applications for Disease Treatment and Tissue Regeneration
share announcement

Biomedical Devices—Applications for Disease Treatment and Tissue Regeneration

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: closed (31 May 2026) | Viewed by 7424

Editor

Dr. Eleni Papachristou

E-Mail Website
Guest Editor
Laboratory of Chemical Engineering A, School of Chemical Engineering, Faculty of Engineering, Aristotle, University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece
Interests: biomedical devices mesenchymal stem cell therapy; apoptosis; differentiation; biomaterials; cell cycle; cancer; mRNA therapeutics

Special Issue Information

Dear Colleagues,

This Special Issue, “Biomedical Devices—Applications for Disease Treatment and Tissue Regeneration”, will focus on using biomedical devices and biomaterials for the treatment of degenerative disorders.  It will focus on the use of biomaterials and biochips targeting disease treatments and tissue regeneration. 

Mesenchymal stem cell therapy based on nanotechnology, pharmacophore encapsulation in nanomaterials and drug delivery systems, tissue engineering, and the use of "smart biomedical devices" to deliver bioactive signals for tissue regeneration are all examples of contemporary approaches to treating diseases.

It will involve three approaches, often in combination with each other: (a) therapies using tissue-regenerating cells, (b) therapies using growth factors that promote tissue cell proliferation and differentiation, and (c) therapies using biocompatible scaffolds.

Within this Special Issue, we will discuss current advances in biomaterials, biomedical device research, tissue engineering applications, drug delivery systems, nanotechnology-based disease detection systems, and the development of innovative therapeutic approaches using biomaterials.

This Special Issue is open for the submission of basic and clinical research, or that taking a multidisciplinary approach, and will also cover original articles and reviews on the following topics:

  • Novel therapeutic approaches including biomedical devices.
  • Biomaterial-based mesenchymal stem cell therapy.
  • Bioactive signal delivery for mesenchymal stem cell differentiation.
  • Application of biomedical applications in osteogenesis, chondrogenesis, angiogenesis, neurogenesis, etc.
  • Clinical trials/research on biomedical devices.
  • Tissue engineering.
  • Cancer.

Dr. Eleni Papachristou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical devices
  • mesenchymal stem cell
  • biomedical applications
  • Tissue engineering

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

18 pages, 8857 KB  
Article
Biomimetic Porous Coatings on a Biocompatible Ti-15Mo Alloy as a Platform for Local Delivery of Anticancer Drugs to Patient Tissues
by Svetlana Gatina, Ruzil Farrakhov, Alfiz Gareev, Azat Sabitov, Nariman A. Enikeev, Natalia Anisimova and Mikhail Kiselevskiy
Biomedicines 2025, 13(11), 2779; https://doi.org/10.3390/biomedicines13112779 - 14 Nov 2025
Viewed by 936
Abstract
Background and Objectives: Currently, the development of local drug delivery systems for the treatment of cancer patients is a pressing issue. Such systems allow for the targeted delivery of anticancer drugs directly to the tumor site, ensuring prolonged drug release or reducing the [...] Read more.
Background and Objectives: Currently, the development of local drug delivery systems for the treatment of cancer patients is a pressing issue. Such systems allow for the targeted delivery of anticancer drugs directly to the tumor site, ensuring prolonged drug release or reducing the risk of recurrence after tumor removal, minimizing the impact on healthy tissues and thereby reducing the overall toxic load on the body. This work is devoted to evaluating the prospects of using scaffolds based on low-modulus titanium Ti-15Mo alloy with a biomimetic coating as a platform for the local administration of the cytostatic drug cisplatin into the patient’s body. Methods: Porous coatings were obtained by plasma electrolytic oxidation in an aqueous solution of sodium phosphate and calcium acetate with the addition of various components. The influence of coating parameters on the corrosion resistance of samples and on the antiproliferative effect of cisplatin-loaded scaffolds was evaluated. Human K562 hemoblastosis, HT116 intestinal cancer, and SKOV3 ovarian cancer cell lines were used as cell models. Results: It was shown that the addition of sodium phosphate (the PS type electrolyte) provides the formation of a coating with a developed system of interconnected pores characterized by an attractive combination of parameters: high porosity (17%), high pore size (3.9 μm), and considerable thickness (17.4 μm). This coating demonstrated the best corrosion resistance in a Ringer solution as compared to the other tested states. In addition, the PS coating loaded with cisplatin exhibited a pronounced cytotoxic effect on cancer cells. This effect was attributed to its ability to fix cisplatin on the surface, which slows down its release into the extracellular environment, increasing the time of its action, thereby contributing to a more effective (by more than 3 times) suppression of tumor cell proliferation compared to the action of the standard form of the drug in the form of a solution when changing the growth medium and subsequent incubation for 48 h. Conclusions: PS scaffolds made of low-modulus titanium alloy Ti-15Mo with a biomimetic surface in an electrolyte based on an aqueous solution of sodium phosphate and calcium acetate with the addition of sodium silicate can be used as an advanced platform for the local delivery of the cytostatic drug cisplatin, which makes them promising for application in orthopedic oncology. Full article
(This article belongs to the Special Issue Biomedical Devices—Applications for Disease Treatment and Tissue Regeneration)
►▼ Show Figures

Figure 1

Review

Jump to: Research

22 pages, 1405 KB  
Review
Knee Osteoarthritis Diagnosis: Future and Perspectives
by Henri Favreau, Kirsley Chennen, Sylvain Feruglio, Elise Perennes, Nicolas Anton, Thierry Vandamme, Nadia Jessel, Olivier Poch and Guillaume Conzatti
Biomedicines 2025, 13(7), 1644; https://doi.org/10.3390/biomedicines13071644 - 4 Jul 2025
Cited by 8 | Viewed by 6022
Abstract
The risk of developing symptomatic knee osteoarthritis (KOA) during a lifetime, i.e., pain, aching, or stiffness in a joint associated with radiographic KOA, was estimated in 2008 to be around 40% in men and 47% in women. The clinical and scientific communities lack [...] Read more.
The risk of developing symptomatic knee osteoarthritis (KOA) during a lifetime, i.e., pain, aching, or stiffness in a joint associated with radiographic KOA, was estimated in 2008 to be around 40% in men and 47% in women. The clinical and scientific communities lack an efficient diagnostic method to effectively monitor, evaluate, and predict the evolution of KOA before and during the therapeutic protocol. In this review, we summarize the main methods that are used or seem promising for the diagnosis of osteoarthritis, with a specific focus on non- or low-invasive methods. As standard diagnostic tools, arthroscopy, magnetic resonance imaging (MRI), and X-ray radiography provide spatial and direct visualization of the joint. However, discrepancies between findings and patient feelings often occur, indicating a lack of correlation between current imaging methods and clinical symptoms. Alternative strategies are in development, including the analysis of biochemical markers or acoustic emission recordings. These methods have undergone deep development and propose, with non- or minimally invasive procedures, to obtain data on tissue condition. However, they present some drawbacks, such as possible interference or the lack of direct visualization of the tissue. Other original methods show strong potential in the field of KOA monitoring, such as electrical bioimpedance or near-infrared spectrometry. These methods could permit us to obtain cheap, portable, and non-invasive data on joint tissue health, while they still need strong implementation to be validated. Also, the use of Artificial Intelligence (AI) in the diagnosis seems essential to effectively develop and validate predictive models for KOA evolution, provided that a large and robust database is available. This would offer a powerful tool for researchers and clinicians to improve therapeutic strategies while permitting an anticipated adaptation of the clinical protocols, moving toward reliable and personalized medicine. Full article
(This article belongs to the Special Issue Biomedical Devices—Applications for Disease Treatment and Tissue Regeneration)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop