Potential Therapeutic and Diagnostic Use of Extracellular Vesicles in Human Reproduction
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 324
Special Issue Editor
Interests: extracellular vesicles; human reproduction; infertility; sperm; oocyte; embryo; implantation; fertilization
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent years, extracellular vesicles (EV) have emerged as one of the most intriguing research foci in the many fields of medicine. These nano-sized vesicles, which are released into the extracellular matrix by cells, have a tremendous potential to act as non-invasive diagnostic or prognostic tools. EVs are membrane-bound vesicles that bud off the host cell with their molecular cargo consisting of nucleic acids, proteins, and lipids. This molecular cargo will eventually be taken up by the recipient cell and will alter epigenetic modifications within the cell. Because of their unique perspective applications, EVs are regarded as the next generation of nanomedicine-based treatments in many medical fields, including human reproduction.
Indeed, EVs play an important part in human reproduction across a broad spectrum of physiological processes. Vesicles in seminal plasma are necessary for human fertility for a variety of reasons, including the promotion of sperm maturation and motility and the induction of immunological tolerance of the female immune system to spermatozoa. EVs are also necessary for the maturation of gametes and embryo development during assisted reproduction. Additionally, trophoblast-derived EVs are essential for the development of the placenta, embryo implantation, and embryo–maternal communication. This Special Issue focuses on the prospects of using EVs for therapeutic and diagnostic purposes, as well as the possibility of using EVs to predict fertilization success.
Dr. Ahmet Ayaz
Guest Editor
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Keywords
- extracellular vesicles
- human reproduction
- infertility
- sperm
- oocyte
- embryo
- implantation
- fertilization
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