Advances in Periodontal Disease and Systemic Disease

Dear Colleagues,

This Special Issue focuses on the rapidly advancing understanding of the bidirectional links between periodontal diseases and systemic health. Emerging evidence from molecular biology, genomics, and microbiome research has uncovered intricate mechanisms through which oral dysbiosis contributes to cardiovascular disease, diabetes, neurodegeneration, cancer, and immune dysfunction. We welcome original research and comprehensive reviews that explore novel biomarkers, therapeutic targets, and precision medicine strategies to improve periodontal–systemic health outcomes. Topics of interest include hematogenous bacterial dissemination, inflammatory mediator networks, oxidative stress, oral–gut–brain axes, and translational applications of multi-omics technologies. We particularly encourage submissions on AI-assisted diagnostic tools, personalized treatment approaches, and clinical validation of biomarker-guided interventions. By highlighting these recent advances, this Special Issue aims to provide an integrated perspective that bridges basic science and clinical practice, fostering the development of evidence-based periodontal medicine that not only improves oral health but also contributes to overall systemic well-being.

Dr. Hye-Sun Shin
Guest Editor

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