Tissue Engineering Updates and Perspectives in Dentistry—Second Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 1279

Special Issue Editors


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Guest Editor
Department of Surgical Sciences, University of Torino, Via Nizza 230, 10126 Torino, Italy
Interests: dentistry; bone tissue engineering; dental implants; dental materials; oral rehabilitation
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Guest Editor
CIR Dental School, Department of Surgical Sciences, University of Torino, Torino, Italy
Interests: bone regeneration; biomaterials; dental implants; MSCs differentiation; bone substitute materials; biological interfaces
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The remarkable advancements of stem cell biology and the progress made in the field of biomaterial research are prompting an impressive development of protocols based on regenerative techniques in dentistry. Clinical applications range between pulp revitalization procedures, guided tissue regeneration, and stem cell implantation for hard and soft tissue repair. While grafts and membranes were used for guided tissue regeneration in the past, technological advancements are now constantly pushing the boundaries further. Thus, new dental techniques are continuously bridging the gap between research and clinical application. As the Guest Editor of this Special Issue of Biomedicines (Publisher MDPI, St Alban-Anlage 66, Basel, Switzerland; IF 2019: 4.717), I would like to invite colleagues who have experience in both the dental and biological fields and who are experts in dental tissue engineering to submit their latest research.

This Special Issue aims to report on the state of the art of basic, translational, and clinical research in the tissue engineering field that can provide fellow dentists and researchers of various specialties with information on regenerative techniques.

Topics of interest for this Special Issue include, but are not limited to, the following:

  • Bases of bone physiology;
  • Wound healing;
  • Biomaterials used in dentistry;
  • Growth factors for dental use;
  • Implant surface treatment;
  • Surgical techniques of bone regeneration;
  • Regeneration aspects in conservative dentistry;
  • Regeneration aspects in periodontal therapy;
  • Regeneration aspects in implantology;
  • Mesenchymal stem cells;
  • State of the art of clinical applications of stem cells in bone regeneration.

It is my pleasure to invite you to submit a manuscript to this Special Issue. Full papers and reviews are welcome.

Dr. Federico Mussano
Prof. Dr. Giulio Preti
Dr. Davide Cavagnetto
Guest Editors

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Keywords

  • bone physiology
  • wound healing
  • dentistry

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Published Papers (1 paper)

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19 pages, 948 KiB  
Review
Suppressing the Aging Phenotype of Mesenchymal Stromal Cells: Are We Ready for Clinical Translation?
by Ilaria Roato, Matteo Visca and Federico Mussano
Biomedicines 2024, 12(12), 2811; https://doi.org/10.3390/biomedicines12122811 - 11 Dec 2024
Viewed by 990
Abstract
Mesenchymal stem/stromal cells (MSCs) are involved in the maintenance and regeneration of a large variety of tissues due to their stemness and multi-lineage differentiation capability. Harnessing these advantageous features, a flurry of clinical trials have focused on MSCs to treat different pathologies, but [...] Read more.
Mesenchymal stem/stromal cells (MSCs) are involved in the maintenance and regeneration of a large variety of tissues due to their stemness and multi-lineage differentiation capability. Harnessing these advantageous features, a flurry of clinical trials have focused on MSCs to treat different pathologies, but only few protocols have received regulatory approval so far. Among the various causes hindering MSCs’ efficacy is the emergence of cellular senescence, which has been correlated with specific characteristics, such as morphological and epigenetic alterations, DNA damage, ROS production, mitochondrial dysfunction, telomere shortening, non-coding RNAs, loss of proteostasis, and a peculiar senescence-associated secretory phenotype. Several strategies have been investigated for delaying or even hopefully reverting the onset of senescence, as assessed by the senescent phenotype of MSCs. Here, the authors reviewed the most updated literature on the potential causes of senescence, with a particular emphasis on the current and future therapeutic approaches aimed at reverting senescence and/or extending the functional lifespan of stem cells. Full article
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