Biomedical and Biochemical Basis of Neurodegenerative Diseases

Dear Colleagues,

In most brain-related diseases, neurodegeneration has been shown to be the primary pathophysiological alteration, and several different neurological conditions are referred to as neurodegenerative diseases. Memory, cognition, behavior, sensory function, and/or motor function are all negatively impacted by the degeneration of neural networks and the loss of neurons, which are incapable of efficiently renewing themselves because they are terminally differentiated. This leads to the breakdown of the fundamental communication circuitry. An individual may exhibit more than one neurodegenerative disease process, and the protein abnormalities that characterize neurodegenerative disorders might exist before the beginning of clinical symptoms. Currently, diagnostic biomarkers are unavailable, with the exception of rare instances in which the condition may be demonstrated to be caused by a causal genetic mutation. In addition to the diagnosis, the neurodegenerative diseases field needs new clinical, pathological, pharmacological, and genetic research. Instead, the age of onset, the sex of patient, the duration of symptoms, clinical diagnosis, the clinical markers of disease severity, the density and distribution of different pathologic processes, and the pharmacogenetic and pharmacokinetic characteristics of treatment should be investigated to achieve an increasingly better management of individual patients.

This proposed Special Issue aims to collect studies that provide clinical, biochemical, and therapeutic evidence on neurodegenerative diseases. In particular, we welcome original research articles and reviews, including but not limited to the following topics:

• The biochemistry of neurodegenerative diseases.
• The clinical basis of neurodegenerative diseases.
• The genetics of neurodegenerative diseases.
• Genetic influence on drug pharmacokinetics and pharmacodynamics in neurodegenerative diseases.
• Combining therapeutic drug monitoring (TDM) with genetics in neurodegenerative diseases treatment.
• Personalized medicine in neurodegenerative diseases.
• Sex differences in neurodegenerative diseases.

Dr. Sarah Allegra
Guest Editor

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