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Biomedicines
Special Issues
Imaging Studies on Neurological Diseases
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Imaging Studies on Neurological Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2398

Special Issue Editors

Dr. Enchao Qiu

E-Mail Website
Guest Editor
Jefferson Headache Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Interests: neurology; neuroimaging; dementia; Parkinson’s disease; depression; headache, epilepsy
Ms. Wei Huang

E-Mail Website
Guest Editor Assistant
Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Interests: stroke; cerebrovascular; endovascular; neurology

Special Issue Information

Dear Colleagues,

For many neurological diseases, the pathophysiological mechanisms are not clear, and there is a lack of neuroimaging biomarkers. Over the past two decades, neuroimaging studies such as MRI and PET have provided a lot of information for neurological disorders. Especially noninvasive functional MRI and diffusion tensor imaging have achieved great progress in these disorders, such as dementia, Parkinson’s disease, depression, headache, epilepsy, etc. These studies are still the areas of focus. Therefore, the aim of the Special Issue is to focus on neuroimaging studies (especially noninvasive functional MRI and diffusion tensor imaging) on neurological diseases to help neurologists to better understand the trends in these fields.

Dr. Enchao Qiu
Ms. Wei Huang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurology
  • neuroimaging
  • noninvasive functional MRI
  • diffusion tensor imaging
  • MRI
  • PET

Published Papers (2 papers)

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Research

14 pages, 1654 KiB  
Article
Comparative Study between the Diagnostic Effectiveness of Brain SPECT with [123I]Ioflupane and [123I]MIBG Scintigraphy in Multiple System Atrophy
by Javier Villena-Salinas, Simeón José Ortega-Lozano, Tomader Amrani-Raissouni, Eduardo Agüera-Morales and Javier Caballero-Villarraso
Biomedicines 2024, 12(1), 102; https://doi.org/10.3390/biomedicines12010102 - 3 Jan 2024
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Abstract
Background: Multiple system atrophy (MSA) is a neurodegenerative disease. It has a fast progression, so early diagnosis is decisive. Two functional imaging tests can be involved in its diagnosis: [123I]Ioflupane SPECT and [123I]MIBG scintigraphy. Our aim is to comparatively [...] Read more.
Background: Multiple system atrophy (MSA) is a neurodegenerative disease. It has a fast progression, so early diagnosis is decisive. Two functional imaging tests can be involved in its diagnosis: [123I]Ioflupane SPECT and [123I]MIBG scintigraphy. Our aim is to comparatively analyze the diagnostic performance of both techniques. Methods: 46 patients (24 males and 22 females) with MSA underwent [123I]Ioflupane SPECT and [123I]MIBG scintigraphy. In each of these techniques, qualitative assessment was compared with quantitative assessment. Results: SPECT visual assessment was positive in 93.5% of subjects (S = 95.24%; PPV = 93.02%). A cut-off of 1.363 was established for overall S/O index (S = 85.7%, E = 100%). Visual assessment of scintigraphy was positive in 73.1% (S = 78.57%, PPV = 94.29%). For the delayed heart/medistinum ratio (HMR) a cut-off of 1.43 (S = 85.3, E = 100%) was obtained. For each unit increase in delayed HMR, the suspicion of MSA increased by 1.58 (OR = 1.58, p < 0.05). The quantitative assessment showed an association with the visual assessment for each technique (p < 0.05). Conclusions: Both tests are useful in MSA diagnosis. Comparatively, we did not observe a clear superiority of either. Striatal and myocardial deterioration do not evolve in parallel. Qualitative assessment is crucial in both techniques, together with the support of quantitative analysis. Delayed HMR shows a direct relationship with the risk of MSA. Full article
(This article belongs to the Special Issue Imaging Studies on Neurological Diseases)
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9 pages, 650 KiB  
Article
Follow-Up Findings in Multiple System Atrophy from [123I]Ioflupane Single-Photon Emission Computed Tomography (SPECT): A Prospective Study
by Javier Villena-Salinas, Simeón José Ortega-Lozano, Tomader Amrani-Raissouni, Eduardo Agüera and Javier Caballero-Villarraso
Biomedicines 2023, 11(11), 2893; https://doi.org/10.3390/biomedicines11112893 - 26 Oct 2023
Cited by 1 | Viewed by 835
Abstract
Background: Multiple system atrophy (MSA) is subdivided into two types: MSA-P (parkinsonian) and MSA-C (cerebellar). Brain SPECT allows for the detection of nigrostriatal involvement, even in the early stages. To date, the scientific literature does not show a consensus on how to follow-up [...] Read more.
Background: Multiple system atrophy (MSA) is subdivided into two types: MSA-P (parkinsonian) and MSA-C (cerebellar). Brain SPECT allows for the detection of nigrostriatal involvement, even in the early stages. To date, the scientific literature does not show a consensus on how to follow-up MSA, especially MSA-C. Our aim was to analyze the diagnostic effectiveness of repeat [123I]Ioflupane SPECT for the follow-up of MSA. Methods: A longitudinal observational study on 22 MSA patients (11 males and 11 females). Results: Significant changes were obtained in the quantitative SPECT assessments in the three Striatum/Occipital indices. The qualitative SPECT diagnosis did not show differences between the initial and evolving SPECT, but the neurologist’s clinical suspicion did. Our results showed a brain deterioration of around 31% at 12 months, this being the optimal cut-off for differentiating a diseased subject (capable of solving diagnostic error rate). Previous imaging tests were inconclusive, as they showed less deterioration in the SPECT and quantitative assessments with respect to the group of confirmed patients. Repeated SPECT increased the diagnostic sensitivity (50% vs. 75%) and positive predictive value (72.73% vs. 77%). In addition, repeated SPECT proved decisive in the diagnosis of initial inconclusive cases. Conclusion: Repeat SPECT at 12 months proves useful in the diagnosis and follow-up of MSA. Full article
(This article belongs to the Special Issue Imaging Studies on Neurological Diseases)
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