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Biomedicines
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Unraveling New Horizon in Vascular Diseases: From Pathophysiology to Novel...
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Unraveling New Horizon in Vascular Diseases: From Pathophysiology to Novel Therapeutic

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1135

Special Issue Editors

Prof. Dr. Miguel A. Ortega

E-Mail Website
Guest Editor
Department of Medicine and Medical Specialties, IRYCYS, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain
Interests: vascular diseases; artery; venous disease; venous hypertension; heart; lymph; diabetes; immune system; translational medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Raul Diaz-Pedrero

E-Mail Website
Guest Editor
1. Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, Spain
2. Department of General and Digestive Surgery, University Hospital Príncipe de Asturias, Madrid, Spain
Interests: surgery; abdominal wall; vascular diseases; artery; venous disease; venous hypertension; heart; lymph; diabetes; translational medicine

Special Issue Information

Dear Colleagues,

Vascular pathologies represent one of the greatest challenges of our time. It is estimated that they will be one of the most prevalent pathologies and will cause the greatest mortality and loss of quality of life in the coming decades. All of this makes it necessary for clinical, biomedical, and technological research to focus on improving the understanding of vascular diseases in order to guarantee a real and effective translation of research. In this sense, our Special Issue aims to be a meeting point for a large number of professionals who have a vocation for understanding and translation in vascular pathologies as a whole. For this reason, we want to accommodate the three pillars of vascular pathology (arterial, venous, and lymphatic).

Prof. Dr. Miguel A. Ortega
Dr. Raul Diaz-Pedrero
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vascular diseases
  • artery
  • venous disease
  • venous hypertension
  • heart
  • lymph
  • diabetes
  • surgery
  • immune system
  • translational medicine

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Published Papers (1 paper)

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Research

23 pages, 3030 KiB  
Article
Evidence of Inflammatory Network Disruption in Chronic Venous Disease: An Analysis of Circulating Cytokines and Chemokines
by Oscar Fraile-Martinez, Cielo García-Montero, Ana María Gomez-Lahoz, Felipe Sainz, Julia Bujan, Silvestra Barrena-Blázquez, Laura López-González, Raul Díaz-Pedrero, Melchor Álvarez-Mon, Natalio García-Honduvilla, Miguel A. Saez, Jorge Monserrat and Miguel A. Ortega
Biomedicines 2025, 13(1), 150; https://doi.org/10.3390/biomedicines13010150 - 9 Jan 2025
Cited by 1 | Viewed by 965
Abstract
Background: Chronic venous disease (CVD) comprises a set of vascular disorders that affect the venous system with important local and systemic repercussions. A growing body of evidence displays the relationship between suffering from CVD and a marked deregulation of the immune inflammatory system. [...] Read more.
Background: Chronic venous disease (CVD) comprises a set of vascular disorders that affect the venous system with important local and systemic repercussions. A growing body of evidence displays the relationship between suffering from CVD and a marked deregulation of the immune inflammatory system. In this sense, the previous literature has reported some significant changes in the level of various circulating inflammatory parameters in these patients. However, more research is required to detail and deepen this complex relationship. Methods: In this work, we studied, using a multiplex technique, the levels of circulating cytokines and chemokines detectable in the serum of 40 patients with CVD and compared it with 38 healthy controls (HCs). In parallel, we performed Spearman’s correlation analysis to explore potential inflammatory networks in CVD. Results: In this study, we measured circulating cytokines and chemokines in CVD patients using a multiplex assay. Results showed increased levels of several pro-inflammatory mediators (IL-1β, IL-2, IL-5, IL-6, IL-7, IL-8, IL-12, IL-17A, IL-23, TNF-α, IFN-γ, fractalkine, ITAC, and GM-CSF) and a decrease in IL-13, with no significant changes in IL-4, IL-10, IL-21, MIP-1α, MIP-1β, or MIP-3α. The Spearman correlation analysis revealed strong, positive correlations among several inflammatory mediators in HC, particularly between TNF-alpha, IL-1β, IL-17A, and IL-23, forming a highly interconnected cytokine network. In contrast, CVD patients showed fewer, weaker, and distinct correlations, with new associations such as IFN-γ with IL-1β and IL-23, suggesting a disrupted inflammatory profile. Conclusions: The distinct inflammatory profile in CVD patients, characterized by altered cytokine and chemokine levels and a less coordinated cytokine network, underscores the reconfiguration of inflammatory pathways in this condition. These findings highlight potential therapeutic targets aimed at restoring immune balance and mitigating chronic inflammation in CVD. Full article
(This article belongs to the Special Issue Unraveling New Horizon in Vascular Diseases: From Pathophysiology to Novel Therapeutic)
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