The Role of Extracellular Vesicles in Hepatic, Pancreatic and Biliary Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 4838
Special Issue Editors
2. Department of Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Interests: pathogenesis of chronic liver disease; molecular mechanisms of liver fibrosis; pro- and anti-fibrogenic actions of extracellular vesicles
Special Issue Information
Dear Colleagues,
This Special Issue focuses on the role of extracellular vesicles (EVs) in regulating pathogenic processes in the liver, pancreas or biliary system. EVs, such as exosomes and microvesicles, are produced by multiple cell types and carry a complex molecular payload comprising proteins, mRNAs and microRNAs that reflect the varied phenotypic statuses of the producer cells. EVs can traverse intercellular spaces or be transported through bodily fluids, resulting in their delivery to other cells into which EV cargo molecules may be deposited. These cargo molecules’ numerous activities can cause functional alterations in the recipient cell which, in the context of disease, may initiate, exacerbate or drive the progression of pathogenic processes. Conversely, some EVs types exert therapeutic actions and show promise for suppressing or reversing the progression of hepatic, pancreatic or biliary diseases.
We invite contributors to submit original research and review articles discussing any aspect of the EVs involved in hepatic, pancreatic or biliary diseases, such as primary tissue injury, inflammation, fibrosis and cancer. Researchers should limit the focus of their studies of diabetes to the EV biology of pancreatic islet dysfunction.
Potential topics of interest regarding the role of EVs in hepatic, pancreatic or biliary diseases include, but are not limited to, the following research areas:
- Mechanisms that alter the production of EVs during disease;
- Mechanisms of EV-mediated pathogenesis;
- Analysis and functional relevance of EV molecular cargo;
- EV-based disease diagnosis or prognosis;
- EV-mediated therapy.
Dr. David R. Brigstock
Dr. Xinlei Li
Guest Editors
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Keywords
- exosome
- extracellular vesicle
- microvesicle
- steatosis
- hepatitis
- pancreatitis
- hepatocarcinoma
- pancreatic ductal adenocarcinoma
- diabetes
- fibrosis
- bile duct
- liver
- pancreas
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