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Biomedicines
Special Issues
Prostate Cancer: From Pathology to Novel Therapeutic Approaches (2nd Edition)
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Prostate Cancer: From Pathology to Novel Therapeutic Approaches (2nd Edition)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 944

Special Issue Editor

Dr. Gvantsa Kharaishvili

E-Mail Website
Guest Editor
1. Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, 779 00 Olomouc, Czech Republic
2. Department of Human Morphology and Pathology, David Tvildiani Medical University, Tbilisi, Georgia
Interests: molecular pathology of prostate and breast cancer; tumor microenvironment; extracellular matrix; identification of novel therapeutic targets
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Prostate cancer remains the second most common cancer in men, with a diverse course from indolent cases to lethal disease. Understanding of prostate cancer biology, genetics, and molecular pathology has emerged, and several new drugs have improved outcomes of metastatic castrate-resistant prostate cancer. However, several tasks remain to be completed, for example, novel screening biomarkers to complement PSA or credential differentiation of indolent disease from aggressive course, molecular stratification of PCa using advanced approaches, novel treatment strategies for better outcomes in high-risk locally advanced cancer or metastatic disease, and the discovery of surrogate biomarkers for durable overall survival benefit. This Special Issue on “Prostate Cancer: From Pathology to Novel Therapeutic Approaches (2nd Edition)” aims to publish cutting-edge research on both preclinical and clinical studies on prostate cancer, including a comprehensive overview of tumor progression in association with the tumor microenvironment, metabolism, metastatic process, cancer treatment, immune response, or drug resistance. Review articles as well as original studies will be considered for publication. We hope that both academy and clinics working on prostate cancer will find this platform useful. We look forward to receiving exceptional submissions.

Dr. Gvantsa Kharaishvili
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prostate cancer
  • castration-resistant prostate cancer
  • metastatic disease
  • biomarker
  • tumor microenvironment
  • treatment
  • immunotherapy
  • drug resistance

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Published Papers (1 paper)

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Research

14 pages, 1574 KiB  
Article
Efficacy of 177Lu-PSMA-617 Therapy in mCRPC Patients with Liver Metastases: Insights into Survival Outcomes and Predictors of Response
by Ebuzer Kalender, Edanur Ekinci, Umut Elboğa and Ertan Şahin
Biomedicines 2025, 13(3), 569; https://doi.org/10.3390/biomedicines13030569 - 24 Feb 2025
Viewed by 733
Abstract
Objectives: Metastatic castration-resistant prostate cancer (mCRPC) is associated with poor prognosis, particularly in cases of liver metastases. 177Lu-PSMA-617 (commercially known as Pluvicto) is an FDA-approved radioligand therapy for mCRPC patients. This study aimed to evaluate the efficacy of 177Lu-PSMA-617 radioligand therapy [...] Read more.
Objectives: Metastatic castration-resistant prostate cancer (mCRPC) is associated with poor prognosis, particularly in cases of liver metastases. 177Lu-PSMA-617 (commercially known as Pluvicto) is an FDA-approved radioligand therapy for mCRPC patients. This study aimed to evaluate the efficacy of 177Lu-PSMA-617 radioligand therapy (RLT) in mCRPC patients with liver metastases, focusing on progression-free survival (PFS), overall survival (OS), and factors influencing treatment response. Materials and Methods: This retrospective study included mCRPC patients (n = 32) with liver metastases treated with Lu-PSMA-617. Patient data, including prostate-specific antigen (PSA) levels, liver SUVmax values, Lutetium-PSMA therapy cycles, and survival outcomes, were collected. Kaplan–Meier survival analysis was used to calculate PFS and OS, while regression analysis was employed to identify factors associated with treatment response. Results: The median PFS and OS were 6 and 9 months, respectively. Partial regression was observed in patients with significantly lower PSA levels (median: 90.0 ng/mL, range: 22–699 ng/mL, p = 0.001) and liver SUVmax values (median: 17.9, range: 8.3–57.0, p = 0.008). A higher number of Lutetium-PSMA cycles correlated with improved treatment response (p = 0.010) and reduced liver SUVmax values (p = 0.043). Conclusions: Lu-PSMA-617 therapy is effective in managing mCRPC with liver metastases. Increased intensity of therapy exposure, reflected by a higher number of treatment cycles, is associated with a greater biochemical response, as indicated by reduced PSA levels, thereby supporting the rationale for personalized treatment strategies. These findings support the use of Lu-PSMA-617 in mCRPC patients with liver metastases, warranting further prospective studies. Full article
(This article belongs to the Special Issue Prostate Cancer: From Pathology to Novel Therapeutic Approaches (2nd Edition))
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