Nrf2 at the Crossroads of Molecular Mechanisms in Health and Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1846

Special Issue Editors


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Guest Editor
Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, Rokietnicka 8, 60-806 Poznan, Poland
Interests: oxidative stress; redox balance; antioxidants; athersoclersois; inflammation

Special Issue Information

Dear Colleagues,

The transcription factor NRF2 (nuclear factor erythroid 2-related factor 2) has been studied extensively in recent years, and is primarily associated with the regulation of the redox balance in the body. It is a specific cellular transmitter of signals, stimulated by a number of factors related to oxidative stress and inflammation. Under certain conditions, the consequence of its induction is the transcription of a broad group of antioxidant compounds. The involvement of the NRF2 signaling pathway in the development of inflammation is not entirely clear. Recent studies report that the chronic activation of the NRF2 pathway may contribute to the development of reductive stress and intensify the inflammatory process, resulting in disease progression. In order to build a pharmacological therapy based on the activation of NRF2, let us try to explain the consequence of its overexpression in both health and disease. Let us find answers to the questions asking how we might stimulate/induce the NRF2 pathway so as not to lead to the harmful dysregulation of the redox system in the body.

The idea behind this Special Issue is therefore to assemble papers exploring the ups and downs of the NRF2 signaling pathway, both in physiological conditions and in disease.

Dr. Magdalena Paulina Kasprzak
Prof. Dr. Dorota Formanowicz
Guest Editors

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Keywords

  • NRF2
  • reductive stress
  • overexpression
  • oxidative stress
  • Keap1
  • antioxidants

Published Papers (1 paper)

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Review

16 pages, 903 KiB  
Review
Anti-Osteoarthritis Mechanism of the Nrf2 Signaling Pathway
by Sarmistha Saha and Nazih Y. Rebouh
Biomedicines 2023, 11(12), 3176; https://doi.org/10.3390/biomedicines11123176 - 29 Nov 2023
Cited by 1 | Viewed by 1440
Abstract
Osteoarthritis (OA) is a chronic degenerative disease and the primary pathogenic consequence of OA is inflammation, which can affect a variety of tissues including the synovial membrane, articular cartilage, and subchondral bone. The development of the intra-articular microenvironment can be significantly influenced by [...] Read more.
Osteoarthritis (OA) is a chronic degenerative disease and the primary pathogenic consequence of OA is inflammation, which can affect a variety of tissues including the synovial membrane, articular cartilage, and subchondral bone. The development of the intra-articular microenvironment can be significantly influenced by the shift of synovial macrophages between pro-inflammatory and anti-inflammatory phenotypes. By regulating macrophage inflammatory responses, the NF-κB signaling route is essential in the therapy of OA; whereas, the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway appears to manage the relationship between oxidative stress and inflammation. Additionally, it has been demonstrated that under oxidative stress and inflammation, there is a significant interaction between transcriptional pathways involving Nrf2 and NF-κB. Studying how Nrf2 signaling affects inflammation and cellular metabolism may help us understand how to treat OA by reprogramming macrophage behavior because Nrf2 signaling is thought to affect cellular metabolism. The candidates for treating OA by promoting an anti-inflammatory mechanism by activating Nrf2 are also reviewed in this paper. Full article
(This article belongs to the Special Issue Nrf2 at the Crossroads of Molecular Mechanisms in Health and Disease)
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