Regulation of Gene Expression in Immune Cell Development and Function

Dear Colleagues,

Understanding the gene regulatory mechanisms that govern immune cell development and function is essential for advancing fundamental biology. Immune responses depend on tightly controlled regulation at multiple levels, including epigenetic, transcriptional, post-transcriptional, and chromatin-based mechanisms, all of which are influenced by extracellular cues such as cytokines. The roles of noncoding RNAs, enhancers, silencers, transposable elements, and regulatory proteins with distinct functional domains are increasingly recognized as key contributors. Technological advances—particularly in multi-omics, integrative biology, and AI-assisted discovery—are rapidly expanding insights into complex gene regulatory networks. Despite progress, the regulatory mechanisms underlying innate and adaptive immune responses remain only partially understood. This Special Issue invites original research and reviews that explore the gene regulation of immune cells. We aim to compile innovative contributions that deepen our understanding and ultimately inform novel therapeutic strategies.

Dr. Bon Quy Trinh
Guest Editor

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