Special Issue "Regulation of Viral Infection in Diabetes"
Deadline for manuscript submissions: 30 September 2022 | Viewed by 6473
Although there is no “Diabetes Virus”, many viruses have been known to cause diabetes. The recent world-threating COVID-19 pandemic has also been reported to be associated with the induction of diabetes, as well as increased clinical severity in patients with diabetes infected with SARS-CoV-2 virus. The means by which the virus infection causes type 1 diabetes is associated with the high growth rate of the virus in pancreatic β-cells, inflammatory reactions around islets and induction of autoimmunity to β-cells, leading to extensive damage of those cells, resulting in the loss of insulin-secreting activity, and development of type 1 diabetes. The regulatory mechanisms to control virus infection are influenced by the infectivity of the virus to attach the host cells via virus receptors, affecting growth in infected cells and spread of the proliferated virus to surrounding uninfected cells. To resist viral infection, many host factors are operative, mainly the induction of innate and adoptive immunity, such as the interferon and Th1 type immune response. In this Special Issue of Biology, we describe historical, present and future aspects of viral infection in type 1 diabetes and regulatory mechanisms of viral infection in type 1 diabetes, aiming to develop an anti-diabetogenic virus vaccine to prevent virus-induced type 1 diabetes in the near future.
Prof. Dr. Seiho Nagafuchi
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