Platelets – Fine Tuners of Vascular and Inflammatory Diseases

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: closed (20 July 2022) | Viewed by 3446

Special Issue Editors


E-Mail Website
Guest Editor
Institute of Vascular Biology and Thrombosis Research, Centre of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria
Interests: platelets; haemostasis and thrombosis; vascular biology; immunothrombosis; platelet-leukocyte interactions; platelet–pathogen interactions; immune response; infections

E-Mail Website
Guest Editor
Department of Pharmacology and Toxicology, Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria
Interests: platelets; immune cells; fatty liver disease; atherosclerosis; miRNAs; cardiovascular biology; endothelial dysfunction; inflammation

Special Issue Information

Dear Colleagues,

Vascular diseases are among the leading causes of morbidity and mortality worldwide, with manifestations ranging from atherosclerosis and aberrant angiogenesis to devastating bleeding and occlusive thrombosis. Platelets are increasingly becoming recognized as essential participants in these pathologies beyond their function as effectors of thrombotic complications, also linking inflammatory and/or infectious disease with vascular complications. With their ability to regulate angiogenesis and tissue homeostasis and their capacity to sense and modulate the inflammatory processes underlying endothelial dysfunction, the contributions of these small, seemingly inconspicuous cells are manifold.

For this Special Issue, we invite authors to submit research articles and reviews focusing on the cellular and molecular mechanisms involved in vascular diseases, highlighting recent findings on the contribution of platelets as regulators and drivers of vascular diseases, their interplay with vascular and immune cells, and/or their potential to act as targets for diagnostic, preventive, and interventive treatment. We welcome clinical studies as well as studies involving cell culture techniques and mouse models with the aim of expanding current knowledge on the versatile roles of platelets in the complex variety of vascular diseases.

We ask authors to submit an abstract prior to article submission to make sure that their work falls within the scope of this Special Issue.

Sincerely, 

Dr. Waltraud C. Schrottmaier
Dr. Marion Mussbacher
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vascular inflammation
  • vascular disease
  • platelets
  • anti-platelet therapy
  • endothelial dysfunction
  • angiogenesis
  • infection
  • thrombosis
  • atherosclerosis
  • platelet–leukocyte aggregates

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

15 pages, 2337 KiB  
Article
Dysregulation in the Expression of Platelet Surface Receptors in Acute Coronary Syndrome Patients—Emphasis on P2Y12
by Rafał Szelenberger, Michał Seweryn Karbownik, Michał Kacprzak, Ewelina Synowiec, Sylwia Michlewska, Michał Bijak, Marzenna Zielińska, Alina Olender and Joanna Saluk-Bijak
Biology 2022, 11(5), 644; https://doi.org/10.3390/biology11050644 - 22 Apr 2022
Cited by 1 | Viewed by 2571
Abstract
The pathological conditions caused by blood platelet activation constitute a fundamental core in the pathogenesis of Acute Coronary Syndrome (ACS). The hyperactivity of platelets in ACS is well-documented, but there is still little research into the molecular basis of phenotypic changes in platelet [...] Read more.
The pathological conditions caused by blood platelet activation constitute a fundamental core in the pathogenesis of Acute Coronary Syndrome (ACS). The hyperactivity of platelets in ACS is well-documented, but there is still little research into the molecular basis of phenotypic changes in platelet functionality. To expand the knowledge of this phenomenon, we analyzed the disturbances in the expression of several key platelet receptors and the aspect of regulating potential abnormalities. Platelet surface receptors are responsible for maintaining the hemostatic balance, platelet interaction with immune cells, and support of the coagulation cascade leading to occlusion of the vessel lumen. Due to their prominent role, platelet receptors constitute a major target in pharmacological treatment. Our work aimed to identify the molecular alteration of platelet surface receptors, which showed augmented mRNA expression of P2Y12, GP1BB, ITGA2B, and ITGB3 and increased protein concentrations of P2Y12 and GP IIb/IIIa in ACS. The upregulation of the P2Y12 level was also confirmed by confocal and cytometric visualization. Furthermore, we evaluated the expression of two microRNAs: miR-223-3p and miR-126-3p, which were suggested to regulate platelet P2Y12 expression. Results of our study present new insight into the molecular background of ACS. Full article
(This article belongs to the Special Issue Platelets – Fine Tuners of Vascular and Inflammatory Diseases)
Show Figures

Figure 1

Back to TopTop