Muscle Structure and Function

Dear Colleagues,

Muscle is amazingly adaptable. Over a long time scale, a variety of muscle types have evolved to perform distinct and specialized functions based on a well conserved design of interdigitating myofilaments. Over a short time scale, muscle adapts to exercise and training by undergoing biochemical, metabolic, and structural remodeling. Muscle relies on different mechanisms to supply energy for contractile and homeostatic processes and increasing evidence suggests a variety of strategies by which energy production and transfer is regulated in different muscles and in muscles subjected to acute exercise and training. Cell biology research over the past decade has increasingly demonstrated a high degree of cytoplasmic compartmentalization defined not by structural boundaries, but by transient molecular interactions among pathway components and cellular structures. For this special issue, we welcome original research and review articles that examine muscle metabolism, in health and disease, in light of the emerging paradigm of the cytoplasm as an interconnected network of microdomains.

Prof. Dr. Jim O. Vigoreaux
Guest Editor

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