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The Structural and Functional Coordination of Glycolytic Enzymes in Muscle: Evidence of a Metabolon?

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Department of Biology, University of Vermont, Burlington, VT 05405, USA
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Department of Molecular Physiology & Biophysics, University of Vermont, Burlington, VT 05405, USA
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Author to whom correspondence should be addressed.
Biology 2014, 3(3), 623-644; https://doi.org/10.3390/biology3030623
Received: 14 July 2014 / Revised: 5 September 2014 / Accepted: 8 September 2014 / Published: 22 September 2014
(This article belongs to the Special Issue Muscle Structure and Function)
Metabolism sustains life through enzyme-catalyzed chemical reactions within the cells of all organisms. The coupling of catalytic function to the structural organization of enzymes contributes to the kinetic optimization important to tissue-specific and whole-body function. This coupling is of paramount importance in the role that muscle plays in the success of Animalia. The structure and function of glycolytic enzyme complexes in anaerobic metabolism have long been regarded as a major regulatory element necessary for muscle activity and whole-body homeostasis. While the details of this complex remain to be elucidated through in vivo studies, this review will touch on recent studies that suggest the existence of such a complex and its structure. A potential model for glycolytic complexes and related subcomplexes is introduced. View Full-Text
Keywords: glycolytic metabolon; enzyme complex; muscle; metabolism; homeostasis glycolytic metabolon; enzyme complex; muscle; metabolism; homeostasis
MDPI and ACS Style

Menard, L.; Maughan, D.; Vigoreaux, J. The Structural and Functional Coordination of Glycolytic Enzymes in Muscle: Evidence of a Metabolon? Biology 2014, 3, 623-644.

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